Disease Markers / 2019 / Article / Tab 3

Research Article

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

Table 3

The association between the ADRB3 rs4994 genotype and the risk of NAFLD in normal-weight and overweight/obese subjects.

Weight statusADRB3 genotypeNAFLDOR [95% CI] value
AbsentPresent

Normal-weightT/T184 (94.8)10 (5.2)1
T/C92 (92.0)8 (8.0)1.92 [0.67–5.51]0.18
C/C12 (100.0)0 (0.0)

Overweight/obeseT/T115 (66.9)57 (33.1)1
T/C65 (63.7)37 (36.3)1.29 [0.73–2.29]0.39
C/C4 (36.4)7 (63.6)4.40 [1.08–17.93]0.04

OverweightT/T107 (69.5)47 (30.5)1
T/C61 (68.5)28 (31.5)1.17 [0.63–2.19]0.62
C/C3 (37.5)5 (62.5)6.18 [1.25–30.64]0.03

ADRB3: beta-3-adrenergic receptor; NAFLD: nonalcoholic fatty liver disease; OR: odds ratio; CI: confidence interval. Data are the number (%). Adjusted by age, HOMA-IR, and dyslipidemia. Analyzed using a logistic regression analysis.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.