Disease Markers / 2019 / Article / Tab 5

Research Article

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

Table 5

The clinical characteristics of the normal-weight subjects.

ADRB3 rs4994 genotype
T/T ()T/C ()C/C () value

Male/female97/9751/496/60.98
Age (years)69 (25–89)67 (31–87)70 (54–81)0.15
BMI (kg/m2)20.9 (15.5–22.9)20.8 (15.9–22.9)21.7 (17.2–22.9)0.62
Alcohol intake (%)41.241.050.00.83
Ever smoking (%)28.430.041.70.55
Systolic BP (mmHg)118 (75–182)118 (98–177)130 (94–163)0.19
Diastolic BP (mmHg)69 (44–102)70 (50–96)71 (64–93)0.15
LDL_C (mg/dL)118 (57–188)118 (38–178)128 (74–145)0.85
HDL_C (mg/dL)72 (39–119)74 (35–128)68 (45–114)0.59
Triglyceride (mg/dL)78 (26–520)85 (31–349)87 (45–172)0.68
AST (IU/L)22 (12–39)22 (14–34)24 (18–46)0.26
ALT (IU/L)17 (7–51)18 (7–71)19 (11–36)0.34
GGT (IU/L)18 (8–302)21 (8–177)20 (12-57)0.27
HbA1c (%)5.4 (4.8–7.6)5.3 (3.8–8.4)5.3 (4.9–7.4)0.26
Fasting plasma glucose (mg/dL)94 (74–162)95 (73–206)94 (78–131)0.51
Fasting serum insulin (μU/mL)3.4 (0.7–33.3)4.0 (1.1–19.0)3.1 (1.9–9.5)0.17
HOMA-IR0.8 (0.1–7.8)1.0 (0.2–5.2)0.7 (0.4–3.1)0.06
Hypertension (%)31.433.041.70.72
Diabetes (%)9.812.08.30.83
Dyslipidemia (%)45.946.041.71.00
NAFLD (%)5.28.00.00.52

Data are the median (range) or proportion for categorical variables. ADRB3: beta-3-adrenergic receptor; BMI: body mass index; BP: blood pressure; LDL_C: low-density lipoprotein cholesterol; HDL_C: high-density lipoprotein cholesterol; AST: aspartate transaminase; ALT: alanine transaminase; GGT: γ-glutamyltransferase; HbA1c: hemoglobin A1c; HOMA-IR: homeostasis model assessment for insulin resistance; NAFLD: nonalcoholic fatty liver disease. Calculated among 214 subjects for whom information could be collected. Calculated among 281 subjects for whom information could be collected. Analyzed by Fisher’s exact test, otherwise Kruskal Wallis test.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.