Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

Table 6

The association between the ADRB3 rs4994 genotype and the BMI or HOMA-IR values in normal-weight and overweight/obese subjects.

Dependent variables	Weight status	ADRB3 genotype		SE	value^†
BMI	Normal-weight	T/T (194)	0
		T/C (100)	0.06	0.20	0.75
		C/C (12)	0.39	0.48	0.43
	Overweight/obese	T/T (172)	0
		T/C (102)	-0.14	0.28	0.62
		C/C (11)	1.43	0.68	0.04
HOMA-IR	Normal-weight	T/T (181)	0
		T/C (89)	0.13	0.10	0.18
		C/C (11)	0.07	0.23	0.77
	Overweight/obese	T/T (159)	0
		T/C (97)	-0.09	0.16	0.62
		C/C (11)	0.78	0.38	0.04

ADRB3: beta-3-adrenergic receptor; SE: standard error. Data are the number (%). Adjusted by age, diabetes, and dyslipidemia. ^†Analyzed using a multiple linear regression analysis.