Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

Table 9

Association between the risk of NAFLD during the observation period (year) and the combination of weigh status at baseline and the ADRB3 rs4994 genotype in the Cox proportional hazard model.

Weight status	ADRB3 genotype	HR [95% CI]	value
Normal-weight	T allele	1; 3.66 [0.45–30.15]	0.23
	C/C
Overweight/obese	T allele	3.53 [1.42–8.79]	<0.01
	C/C	10.03 [2.04–49.37]	<0.01

ADRB3: beta-3-adrenergic receptor; NAFLD: nonalcoholic fatty liver disease; HR: hazard ratio; CI confidence interval. Adjusted by age, HOMA-IR, and dyslipidemia. Analyzed using a Cox proportional hazard model.