Differentially methylated regions in patients and controls. (a) The distribution of hypermethylated and hypomethylated loci located in exon, intron, promoter, and other genomic features. (b) Representation of the distribution of hypomethylated (green) and hypermethylated (red) regions across patient genomes. (c) Heat map of total 3013 DMRs, including 445 hypermethylated and 2568 hypomethylated. (d) Heat map of DMRs located in promoter regions in both patients and controls. (e) Top diseases and bio functions by IPA analysis for genes with the hypermethylated promoters.