Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population
Table 5
Joint and multiplication interaction between gene dominant model and environmental factors.
Genotype
Environment
Case (%)
Control (%)
OR (95% CI)
aOR (95% CI)#
rs13409
rs13409 with pollution near the place of residence
CC
No
414 (40.5)
429 (40.7)
1.000
1.000
CC
Yes
98 (9.6)
37 (3.5)
2.745 (1.837-4.101)
2.467 (1.595-3.816)
CT+TT
No
410 (40.1)
540 (51.3)
0.787 (0.653-0.948)
0.760 (0.617-0.936)
CT+TT
Yes
100 (9.8)
47 (4.5)
2.205 (1.520-3.198)
1.980 (1.316-2.977)
rs13409 × pollution near the place of residence
ORmultiply (95% CI)
2.322 (1.623-3.321)
2.119 (1.432-3.138)
rs13409 with house type
CC
No
174 (17.0)
80 (7.6)
1.000
1.000
CC
Yes
338 (33.1)
386 (36.7)
0.403 (0.298-0.545)
0.504 (0.358-0.711)
CT+TT
No
174 (17.0)
93 (8.8)
0.860 (0.597-1.240)
0.761 (0.510-1.136)
CT+TT
Yes
336 (32.9)
494 (46.9)
0.313 (0.232-0.422)
0.387 (0.276-0.542)
rs13409 × house type
ORmultiply (95% CI)
0.554 (0.464-0.662)
0.627 (0.513-0.766)
rs13409 with ventilation situation
CC
No
17 (1.7)
8 (0.8)
1.000
1.000
CC
Yes
495 (48.4)
458 (43.5)
0.509 (0.217-1.190)
0.654 (0.257-1.665)
CT+TT
No
19 (1.9)
7 (0.7)
1.277 (0.382-4.271)
1.305 (0.350-4.862)
CT+TT
Yes
491 (48.0)
580 (55.1)
0.398 (0.170-1.931)
0.497 (0.196-1.264)
rs13409 × ventilation situation
ORmultiply (95% CI)
0.754 (0.635-0.896)
0.652 (0.533-0.798)
rs13409 with kitchen ventilator
CC
No
215 (21.0)
138 (13.1)
1.000
1.000
CC
Yes
297 (29.1)
328 (31.1)
0.581 (0.446-0.758)
0.973 (0.712-1.330)
CT+TT
No
224 (21.9)
177 (16.8)
0.812 (0.607-1.086)
0.808 (0.583-1.120)
CT+TT
Yes
286 (28.0)
410 (38.9)
0.448 (0.345-0.582)
0.722 (0.530-0.984)
rs13409 × kitchen ventilator
ORmultiply (95% CI)
0.609 (0.507-0.733)
0.771 (0.623-0.954)
rs13409 with COF
CC
No
84 (8.2)
153 (14.5)
1.000
1.000
CC
Yes
428 (41.9)
313 (29.7)
2.491 (1.839-3.374)
2.101 (1.497-2.949)
CT+TT
No
88 (8.6)
182 (17.3)
0.881 (0.609-1.273)
0.855 (0.569-1.286)
CT+TT
Yes
422 (41.3)
405 (38.5)
1.898 (1.407-2.559)
1.572 (1.124-2.197)
rs13409 × COF
ORmultiply (95% CI)
1.125 (0.944-1.342)
0.890 (0.837-0.946)
rs13409 with smoking
CC
No
202 (19.8)
264 (25.1)
1.000
1.000
CC
Yes
310 (30.3)
202 (19.2)
2.006 (1.554-2.588)
1.657 (1.231-2.230)
CT+TT
No
189 (18.5)
361 (34.3)
0.684 (0.531-0.882)
0.641 (0.485-0.849)
CT+TT
Yes
321 (31.4)
226 (21.5)
1.856 (1.446-2.384)
1.496 (1.113-2.011)
rs13409 × smoking
ORmultiply (95% CI)
1.676 (1375-2.042)
1.374 (1.093-1.727)
rs13409 with passive smoking
CC
No
156 (15.3)
267 (25.4)
1.000
1.000
CC
Yes
356 (34.8)
199 (18.9)
3.062 (2.354-3.982)
2.404 (1.081-3.209)
CT+TT
No
151 (14.8)
317 (30.1)
0.815 (0.618-1.075)
0.766 (0.567-1.037)
CT+TT
Yes
359 (35.1)
270 (25.6)
2.276 (1.767-2.930)
1.837 (1.392-2.423)
rs13409 × passive smoking
ORmultiply (95% CI)
1.570 (1.300-1.897)
1.402 (1.138-1.727)
rs13409 with drink alcohol
CC
No
343 (33.6)
329 (31.2)
1.000
1.000
CC
Yes
169 (16.5)
137 (13.0)
1.183 (0.902-1.552)
0.800 (0.581-1.100)
CT+TT
No
328 (32.1)
421 (40.0)
0.747 (0.606-0.921)
0.736 (0.581-0.932)
CT+TT
Yes
182 (17.8)
166 (15.8)
1.052 (0.812-1.363)
0.665 (0.492-0.900)
rs13409 × drink alcohol
ORmultiply (95% CI)
1.158 (0.919-1.458)
0.793 (0.608-1.034)
rs13409 with history of lung disease
CC
No
452 (44.2)
422 (40.1)
1.000
1.000
CC
Yes
60 (5.9)
44 (4.2)
1.273 (0.844-1.920)
1.087 (0.680-1.737)
CT+TT
No
442 (43.2)
542 (51.5)
0.761 (0.634-0.914)
0.724 (0.589-0.889)
CT+TT
Yes
68 (6.7)
45 (4.3)
1.411 (0.946-2.103)
1.364 (0.866-2.147)
rs13409 × history of lung disease
ORmultiply (95% CI)
1.597 (1.084-2.351)
1.596 (1.028-2.477)
rs13409 with family history of cancer
CC
No
403 (39.4)
395 (37.5)
1.000
1.000
CC
Yes
109 (10.7)
71 (6.7)
1.505 (1.082-2.092)
1.495 (1.032-2.167)
CT+TT
No
412 (40.3)
501 (47.6)
0.806 (0.666-0.975)
0.769 (0.620-0.953)
CT+TT
Yes
98 (9.6)
86 (8.2)
1.117 (0.810-1.540)
1.116 (0.777-1.603)
rs13409 × family history of cancer
ORmultiply (95% CI)
1.193 (0.881-1.615)
1.218 (0.865-1.714)
rs6815391
rs6815391 with pollution near the place of residence
TT
No
385 (37.7)
425 (41.1)
1.000
1.000
TT
Yes
92 (9.0)
47 (4.5)
2.161 (1.481-3.152)
1.978 (1.311-2.984)
CT+CC
No
436 (42.7)
522 (50.5)
0.922 (0.764-1.112)
0.862 (0.699-1.064)
CT+CC
Yes
107 (10.5)
39 (3.8)
3.029 (2.047-4.481)
2.516 (1.647-3.845)
rs6815391 × pollution near the place of residence
ORmultiply (95% CI)
2.987 (2.048-4.357)
2.571 (1.710-3.865)
rs6815391 with house type
TT
No
140 (13.7)
73 (7.1)
1.000
1.000
TT
Yes
337 (33.0)
399 (38.6)
0.440 (0.320-0.605)
0.638 (0.444-0.915)
CT+CC
No
194 (19.0)
92 (8.9)
1.100 (0.755-1.602)
1.212 (0.802-1.832)
CT+CC
Yes
349 (34.2)
469 (45.4)
0.388 (0.283-0.532)
0.532 (0.371-0.762)
rs6815391 × house type
ORmultiply (95% CI)
0.625 (0.523-0.747)
0.679 (0.554-0.832)
rs6815391 with ventilation situation
TT
No
15 (1.5)
9 (0.9)
1.000
1.000
TT
Yes
462 (45.3)
463 (44.8)
0.599 (0.259-1.382)
0.668 (0.268-1.667)
CT+CC
No
23 (2.3)
6 (0.6)
2.300 (0.679-7.796)
1.831 (0.481-6.966)
CT+CC
Yes
520 (51.0)
555 (53.7)
0.562 (0.244-1.296)
0.599 (0.241-1.493)
rs6815391 × ventilation situation
ORmultiply (95% CI)
0.896 (0.753-1.065)
0.791 (0.645-0.969)
rs6815391 with kitchen ventilator
TT
No
209 (20.5)
143 (13.8)
1.000
1.000
TT
Yes
268 (26.3)
329 (31.8)
0.557 (0.427-0.728)
0.866 (0.632-1.187)
CT+CC
No
226 (22.2)
164 (15.9)
0.943 (0.704-1.263)
0.834 (0.602-1.156)
CT+CC
Yes
317 (31.1)
397 (38.4)
0.546 (0.422-0.708)
0.823 (0.607-1.114)
rs6815391 × kitchen ventilator
ORmultiply (95% CI)
0.722 (0.602-0.867)
0.927 (0.752-1.144)
rs6815391 with COF
TT
No
89 (8.7)
158 (15.3)
1.000
1.000
TT
Yes
388 (38.0)
314 (30.4)
2.194 (1.626-2.959)
1.824 (1.308-2.544)
CT+CC
No
86 (8.4)
179 (17.3)
0.853 (0.592-1.229)
0.812 (0.542-1.216)
CT+CC
Yes
457 (44.8)
382 (37.0)
2.124 (1.584-2.847)
1.716 (1.239-2.375)
rs6815391 × COF
ORmultiply (95% CI)
1.383 (1.159-1.651)
0.932 (0.876-0.992)
rs6815391 with smoking
TT
No
192 (18.8)
265 (25.7)
1.000
1.000
TT
Yes
285 (27.9)
207 (20.0)
1.900 (1.468-2.460)
1.644 (1.217-2.220)
CT+CC
No
196 (19.2)
353 (34.2)
0.766 (0.594-0.989)
0.727 (0.550-0.962)
CT+CC
Yes
347 (34.0)
208 (20.1)
2.303 (1.788-2.966)
1.839 (1.372-2.463)
rs6815391 × smoking
ORmultiply (95% CI)
2.045 (1.675-2.497)
1.650 (1.316-2.069)
rs6815391 with passive smoking
TT
No
138 (13.5)
258 (25.0)
1.000
1.000
TT
Yes
339 (33.2)
214 (20.7)
2.962 (2.265-3.873)
2.373 (1.771-3.180)
CT+CC
No
173 (17.0)
316 (30.6)
1.024 (0.755-1.351)
0.941 (0.695-1.274)
CT+CC
Yes
370 (36.3)
245 (23.7)
2.823 (2.172-3.670)
2.092 (1.571-2.787)
rs6815391 × passive smoking
ORmultiply (95% CI)
1.831 (1.511-2.218)
1.503 (1.216-1.857)
rs6815391 with drinking alcohol
TT
No
318 (31.2)
330 (31.9)
1.000
1.000
TT
Yes
159 (15.6)
142 (13.7)
1.162 (0.884-1.528)
0.728 (0.529-1.003)
CT+CC
No
356 (34.9)
419 (40.6)
0.882 (0.715-1.087)
0.817 (0.645-1.034)
CT+CC
Yes
187 (18.3)
142 (13.7)
1.367 (1.046-1.785)
0.831 (0.608-1.137)
rs6815391 × drink alcohol
ORmultiply (95% CI)
1.409 (1.111-1.787)
0.978 (0.743-1.287)
rs6815391 with history of lung disease
TT
No
419 (41.1)
436 (42.2)
1.000
1.000
TT
Yes
58 (5.7)
36 (3.5)
1.676 (1.083-2.595)
1.401 (0.851-2.306)
CT+CC
No
477 (46.8)
520 (50.3)
0.955 (0.795-1.146)
0.888 (0.723-1.090)
CT+CC
Yes
66 (6.5)
41 (4.0)
1.675 (1.109-2.529)
1.560 (0.977-2.490)
rs6815391× history of lung disease
ORmultiply (95% CI)
1.674 (1.122-2.496)
1.633 (1.037-2.570)
rs6815391 with family history of cancer
TT
No
385 (37.7)
400 (38.7)
1.000
1.000
TT
Yes
92 (9.0)
72 (7.0)
1.328 (0.946-1.863)
1.350 (0.923-1.975)
CT+CC
No
433 (42.5)
476 (46.1)
0.945 (0.781-1.144)
0.887 (0.715-1.101)
CT+CC
Yes
110 (10.8)
85 (8.2)
1.345 (0.980-1.844)
1.353 (0.949-1.929)
rs6815391 × family history of cancer
ORmultiply (95% CI)
1.348 (1.001-1.815)
1.396 (1.000-1.948)
rs3740535
rs3740535 with pollution near the place of residence
GG
No
464 (44.3)
561 (52.0)
1.000
1.000
GG
Yes
138 (13.2)
53 (4.9)
3.148 (2.241-4.422)
2.846 (1.969-4.115)
GA+AA
No
376 (35.9)
431 (39.9)
1.055 (0.877-1.269)
0.971 (0.789-1.194)
GA+AA
Yes
70 (6.7)
34 (3.2)
2.489 (1.623-3.818)
2.045 (1.276-3.278)
rs3740535 × pollution near the place of residence
ORmultiply (95% CI)
2.200 (1.447-3.344)
1.873 (1.180-2.973)
rs3740535 with house type
GG
No
204 (19.5)
85 (7.9)
1.000
1.000
GG
Yes
398 (38.0)
529 (49.0)
0.313 (0.236-0.417)
0.398 (0.288-0.548)
GA+AA
No
151 (14.4)
93 (8.6)
0.677 (0.471-0.971)
0.618 (0.415-0.920)
GA+AA
Yes
295 (28.1)
372 (34.5)
0.330 (0.246-0.444)
0.425 (0.305-0.593)
rs3740535 × house type
ORmultiply (95% CI)
0.745 (0.619-0.895)
0.845 (0.686-1.040)
rs3740535 with ventilation situation
GG
No
21 (2.0)
10 (0.9)
1.000
1.000
GG
Yes
581 (55.4)
604 (56.0)
0.458 (0.214-0.981)
0.529 (0.227-1.228)
GA+AA
No
18 (1.7)
6 (0.6)
1.429 (0.434-4.705)
1.127 (0.309-4.108)
GA+AA
Yes
428 (40.8)
459 (42.5)
0.444 (0.207-0.954)
0.490 (0.210-1.144)
rs3740535 × ventilation situation
ORmultiply (95% CI)
0.932 (0.785-1.108)
0.800 (0.652-0.980)
rs3740535 with kitchen ventilator
GG
No
249 (23.8)
162 (15.0)
1.000
1.000
GG
Yes
353 (33.7)
452 (41.9)
0.508 (0.399-0.647)
0.809 (0.608-1.076)
GA+AA
No
201 (19.2)
162 (15.0)
0.807 (0.606-1.075)
0.758 (0.550-1.045)
GA+AA
Yes
245 (23.4)
303 (28.1)
0.526 (0.406-0.682)
0.858 (0.632-1.164)
rs3740535 × kitchen ventilator
ORmultiply (95% CI)
0.781 (0.643-0.950)
1.024 (0.819-1.281)
rs3740535 with COF
GG
No
103 (9.8)
211 (19.6)
1.000
1.000
GG
Yes
499 (47.6)
403 (37.3)
2.537 (1.937-3.322)
2.217 (1.641-2.994)
GA+AA
No
77 (7.3)
131 (12.1)
1.204 (0.834-1.738)
1.272 (0.846-1.911)
GA+AA
Yes
369 (35.2)
334 (31.0)
2.263 (1.714-2.989)
1.895 (1.387-2.590)
rs3740535 × COF
ORmultiply (95% CI)
1.212 (1.012-1.453)
0.965 (0.907-1.027)
rs3740535 with smoking
GG
No
246 (23.5)
361 (33.5)
1.000
1.000
GG
Yes
356 (34.0)
253 (23.4)
2.065 (1.643-2.595)
1.729 (1.322-2.261)
GA+AA
No
154 (14.7)
274 (25.4)
0.825 (0.639-1.065)
0.806 (0.608-1.069)
GA+AA
Yes
292 (27.9)
191 (17.7)
2.243 (1.758-2.863)
1.861 (1.395-2.482)
rs3740535 × smoking
ORmultiply (95% CI)
1.796 (1.461-2.208)
1.506 (1.187-1.909)
rs3740535 with passive smoking
GG
No
179 (17.1)
350 (32.4)
1.000
1.000
GG
Yes
423 (40.4)
264 (24.5)
3.133 (2.472-3.970)
2.665 (2.054-3.458)
GA+AA
No
131 (12.5)
245 (22.7)
1.045 (0.792-1.381)
1.085 (0.801-1.470)
GA+AA
Yes
315 (30.1)
220 (20.4)
2.800 (2.182-3.592)
2.256 (1.715-2.969)
rs3740535 × passive smoking
ORmultiply (95% CI)
1.678 (1.376-2.046)
1.424 (1.142-1.774)
rs3740535 with drink alcohol
GG
No
392 (37.4)
450 (41.7)
1.000
1.000
GG
Yes
210 (20.0)
164 (15.2)
1.470 (1.150-1.878)
0.966 (0.725-1.288)
GA+AA
No
292 (27.9)
320 (29.7)
1.048 (0.850-1.290)
1.003 (0.792-1.270)
GA+AA
Yes
154 (14.7)
145 (13.4)
1.219 (0.936-1.588)
0.787 (0.578-1.071)
rs3740535 × drink alcohol
ORmultiply (95% CI)
1.110 (0.869-1.417)
0.794 (0.599-1.053)
rs3740535 with history of lung disease
GG
No
528 (50.4)
564 (52.3)
1.000
1.000
GG
Yes
74 (7.1)
50 (4.6)
1.581 (1.083-2.307)
1.593 (1.034-2.453)
GA+AA
No
395 (37.7)
426 (39.5)
0.990 (0.826-1.187)
0.966 (0.787-1.186)
GA+AA
Yes
51 (4.9)
39 (3.6)
1.397 (0.906-2.155)
1.129 (0.693-1.837)
rs3740535× history of lung disease
ORmultiply (95% CI)
1.364 (0.891-2.088)
1.110 (0.688-1.790)
rs3740535 with family history of cancer
GG
No
485 (46.3)
524 (48.6)
1.000
1.000
GG
Yes
117 (11.2)
90 (8.3)
1.405 (1.039-1.898)
1.388 (0.989-1.949)
GA+AA
No
352 (33.6)
395 (36.6)
0.963 (0.797-1.164)
0.908 (0.733-1.124)
GA+AA
Yes
94 (9.0)
70 (6.5)
1.451 (1.040-2.024)
1.515 (1.043-2.200)
rs3740535 × family history of cancer
ORmultiply (95% CI)
1.420 (1.029-1.959)
1.517 (1.058-2.176)
rs3130932
rs3130932 with pollution near the place of residence
TT
No
362 (34.6)
418 (38.6)
1.000
1.000
TT
Yes
91 (8.7)
35 (3.2)
3.002 (1.984-4.544)
2.806 (1.794-4.389)
GT+GG
No
476 (45.6)
578 (53.4)
0.951 (0.790-1.145)
0.937 (0.762-1.153)
GT+GG
Yes
116 (11.1)
51 (4.7)
2.626 (1.836-3.757)
2.245 (1.513-3.331)
rs3130932 × pollution near the place of residence
ORmultiply (95% CI)
2.524 (1.795-3.550)
2.166 (1.489-3.151)
rs3130932 with house type
TT
No
149 (14.3)
75 (6.9)
1.000
1.000
TT
Yes
304 (29.1)
378 (34.9)
0.405 (0.295-0.555)
0.584 (0.408-0.836)
GT+GG
No
207 (19.8)
103 (9.5)
1.012 (0.703-1.456)
1.099 (0.737-1.638)
GT+GG
Yes
385 (36.8)
526 (48.6)
0.368 (0.271-0.501)
0.509 (0.359-0.723)
rs3130932 × house type
ORmultiply (95% CI)
0.617 (0.519-0.733)
0.701 (0.575-0.854)
rs3130932 with ventilation situation
TT
No
14 (1.3)
7 (0.6)
1.000
1.000
TT
Yes
439 (42.0)
446 (41.2)
0.492 (0.197-1.231)
0.516 (0.190-1.402)
GT+GG
No
24 (2.3)
8 (0.7)
1.500 (0.447-5.029)
1.086 (0.292-4.045)
GT+GG
Yes
568 (54.4)
621 (57.4)
0.457 (0.183-1.141)
0.473 (0.174-1.282)
rs3130932 × ventilation situation
ORmultiply (95% CI)
0.884 (0.745-1.049)
1.638 (1.149-2.334)
rs3130932 with kitchen ventilator
TT
No
204 (19.5)
147 (13.6)
1.000
1.000
TT
Yes
249 (23.8)
306 (28.3)
0.586 (0.448-0.768)
1.036 (0.752-1.427)
GT+GG
No
246 (23.5)
179 (16.5)
0.990 (0.744-1.319)
1.025 (0.744-1.411)
GT+GG
Yes
346 (33.1)
450 (41.6)
0.554 (0.430-0.714)
0.894 (0.662-1.207)
rs3130932 × kitchen ventilator
ORmultiply (95% CI)
0.695 (0.583-0.830)
0.872 (0.711-1.070)
rs3130932 with COF
TT
No
85 (8.1)
150 (13.9)
1.000
1.000
TT
Yes
368 (35.2)
303 (28.0)
2.143 (1.578-2.912)
1.744 (1.238-2.458)
GT+GG
No
96 (9.2)
191 (17.7)
0.887 (0.618-1.274)
0.849 (0.568-1.268)
GT+GG
Yes
496 (47.5)
438 (40.5)
1.998 (1.487-2.685)
1.643 (1.180-2.287)
rs3130932 × COF
ORmultiply (95% CI)
1.328 (1.119-1.577)
0.951 (0.895-1.011)
rs3130932 with smoking
TT
No
170 (16.3)
268 (24.8)
1.000
1.000
TT
Yes
283 (27.1)
185 (17.1)
2.412 (1.847-3.149)
2.016 (1.477-2.752)
GT+GG
No
223 (21.3)
370 (34.2)
0.950 (0.737-1.225)
0.929 (0.702-1.229)
GT+GG
Yes
369 (35.3)
259 (23.9)
2.246 (1.750-2.882)
1.835 (1.372-2.455)
rs3130932 × smoking
ORmultiply (95% CI)
1.735 (1.436-2.095)
1.421 (1.145-1.764)
rs3130932 with passive smoking
TT
No
133 (12.7)
260 (24.0)
1.000
1.000
TT
Yes
320 (30.6)
193 (17.8)
3.241 (2.467-4.267)
2.598 (1.921-3.513)
GT+GG
No
178 (17.0)
340 (31.4)
1.023 (0.776-1.350)
1.006 (0.744-1.361)
GT+GG
Yes
414 (39.6)
289 (26.7)
2.800 (2.165-3.622)
2.237 (1.685-2.970)
rs3130932 × passive smoking
ORmultiply (95% CI)
1.800 (1.499-2.162)
1.548 (1.263-1.897)
rs3130932 with drink alcohol
TT
No
296 (28.3)
325 (30.0)
1.000
1.000
TT
Yes
157 (15.0)
128 (11.8)
1.347 (1.016-1.785)
0.861 (0.621-1.194)
GT+GG
No
385 (36.8)
449 (41.5)
0.941 (0.765-1.159)
0.910 (0.719-1.152)
GT+GG
Yes
207 (19.8)
180 (16.6)
1.263 (0.979-1.628)
0.808 (0.598-1.091)
rs3130932 × drink alcohol
ORmultiply (95% CI)
1.238 (0.993-1.544)
0.872 (0.674-1.129)
rs3130932 with history of lung disease
TT
No
398 (38.1)
417 (38.5)
1.000
1.000
TT
Yes
55 (5.3)
36 (3.3)
1.601 (1.029-2.491)
1.495 (0.909-2.460)
GT+GG
No
524 (50.1)
575 (53.1)
0.955 (0.796-1.145)
0.934 (0.761-1.145)
GT+GG
Yes
68 (6.5)
54 (5.0)
1.319 (0.900-1.935)
1.185 (0.762-1.841)
rs3130932 × history of lung disease
ORmultiply (95% CI)
1.412 (1.065-1.871)
1.205 (0.789-1.843)
rs3130932 with family history of cancer
TT
No
369 (35.3)
387 (35.8)
1.000
1.000
TT
Yes
84 (8.0)
66 (6.1)
1.335 (0.938-1.899)
1.267 (0.855-1.878)
GT+GG
No
467 (44.7)
534 (49.4)
0.917 (0.759-1.108)
0.877 (0.708-1.085)
GT+GG
Yes
125 (12.0)
95 (8.8)
1.380 (1.020-1.867)
1.462 (1.037-2.061)
rs3130932 × family history of cancer
ORmultiply (95% CI)
1.412 (1.065-1.871)
1.537 (1.117-2.116)
#By the degree of education, marital status, BMI, pollution near the place of residence, house type, ventilation situation, COF, kitchen ventilator, smoking, passive smoking, drink alcohol, history of lung disease, and family history of cancer adjusted. OR and its interval shown in italic font to represent the .
