A Preliminary Study of Uric Metabolomic Alteration for Postpartum Depression Based on Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry
Table 2
The differentiating metabolites contributing to the discrimination of urine metabolomic profiles of postpartum depressed patients and healthy controls in the training group.
Metabolite
RT (min)
Ion mode
MS ()
MS/MS ()
VIP value
value
value
Trend
Fold changec
AUC (95% CI)
Sensitivity
Specificity
Alanine
1.7
[M+H]+
90.0557
44
2.97
<0.001
0.007
Upa
1.18
0.722 (0.621-0.827)
0.675
0.675
Methylmalonic acid
1.4
[M-H]-
117.0191
73
4.28
<0.001
<0.001
Up
1.52
0.848 (0.744-0.918)
0.725
0.825
Homocysteine
3.4
[M+H]+
136.0427
118, 90
4.30
<0.001
0.012
Up
1.62
0.852 (0.770-0.931)
0.775
0.800
Tyrosine
3.3
[M+H]+
182.0804
165, 136, 91
4.38
<0.001
0.048
Downb
-1.48
0.859 (0.761-0.920)
0.700
0.850
Glutaric acid
1.6
[M-H]-
131.0346
87, 59
2.77
<0.001
0.019
Up
1.31
0.711 (0.587-0.816)
0.625
0.775
Vanillylmandelic acid
1.9
[M-H]-
197.0450
137
4.33
<0.001
0.029
Up
1.42
0.851 (0.762-0.918)
0.750
0.750
4-Hydroxyhippuric acid
3.8
[M-H]-
194.0461
150, 93
4.71
<0.001
<0.001
Up
1.38
0.884 (0.806-0.946)
0.825
0.825
4-Hydroxybenzoic acid
3.6
[M-H]-
137.0231
93
2.64
<0.001
0.033
Up
1.11
0.714 (0.599-0.831)
0.650
0.725
5-Hydroxyindoleacetic acid
4.9
[M+H]+
192.0647
146, 118
3.39
<0.001
<0.001
Up
1.35
0.752 (0.650-0.836)
0.725
0.650
3-(3-Hydroxyphenyl)-3-hydroxypropionic acid
2.2
[M-H]-
181.0499
137, 119
4.16
<0.001
<0.001
Up
1.63
0.827 (0.725-0.907)
0.825
0.725
RT: retention time; VIP: variable importance in the projection; CI: confidence interval. aThe level in patients is higher than that in controls. bThe level in patients is lower than that in controls. cThe fold change was calculated by dividing the level of metabolite in patients by that in controls.
