Comparison of Performance of Equations for Estimated Glomerular Filtration Rate in Chinese Patients with Biopsy-Proven Diabetic Nephropathy
Table 2
Clinical and pathological characteristics of the not/reclassified group.
Variables
Not reclassified group ()
Reclassified group ()
value
eGFRCKD-EPI-Cr
<0.001
eGFRCKD-EPI-CysC
<0.001
Age (years)
NS
Gender (male) (%)
62 (70.5)
38 (66.7)
NS
Duration of diabetes (months)
0.033
Diabetic retinopathy (%)
28 (32.6)
22 (40.0)
NS
Body mass index (kg/m2)
NS
Systolic blood pressure (mmHg)
NS
Diastolic blood pressure (mmHg)
NS
HbA1C (%)
7.8 (6.8-9.4)
7.5 (6.3-10.2)
NS
Initial proteinuria (g/24 h)
2.4 (0.8-4.8)
4.2 (2.3-8.8)
0.001
Serum creatinine (μmol/L)
<0.001
Cystatin C (mg/L)
<0.001
Triglyceride (mmol/L)
NS
Total cholesterol (mmol/L)
NS
Thyroid-stimulating hormone (mU/L)
2.93 (1.79-4.09) ()
3.86 (2.61-6.58) ()
NS
Free triiodothyronine 3 (pmol/L)
4.41 (3.92-5.10) ()
3.92 (3.46-4.35) ()
0.003
Free triiodothyronine 4 (pmol/L)
15.87 (14.65-17.26) ()
14.54 (12.50-16.66) ()
NS
Pathological lesions
Glomerular classification
<0.001
I
14
1
IIa
39
14
IIb
6
7
III
26
29
IV
3
6
IFTA scores
<0.001
0
8
2
1
62
27
2
18
25
3
0
3
Interstitial inflammation
<0.001
0
17
2
1
70
45
2
1
10
Arteriolar hyalinosis
NS
0
18
10
1
47
28
2
23
19
Follow-up period (months)
NS
Progressed to ESKD (%)
11 (12.5)
21 (36.8)
<0.001
Patients in the reclassified group had significantly longer diabetic duration, heavier proteinuria, and advanced pathological lesions. Data are presented as the and the median with range or counts and percentages. IFTA: interstitial fibrosis and tubular atrophy; NS: not significant. A two-tailed was considered statistically significant.
