Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution

Table 2

Sensitivity and specificity of the “three 7” markers in CHRCC and comparisons of CHRCC with CCRCC, PRCC, and OC.

Markers	Sensitivity	Specificity	CHRCC vs. CCRCC; value	CHRCC vs. PRCC, type 1; value	CHRCC vs. PRCC, type 2; value	CHRCC vs. OC; value
CK7	0.91	0.80	<0.0001	0.5497	<0.0001	<0.0001
CD117	0.94	0.82	<0.0001	<0.0001	<0.0001	0.6546
Claudin-7	0.94	0.78	<0.0001	0.0857	<0.0001	<0.0001
CK7+CD117	0.81	0.95	<0.0001	0.0003	<0.0001	<0.0001
CK7+Claudin-7	0.81	0.97	<0.0001	<0.0001	<0.0001	<0.0001
CD117+Claudin-7	0.85	0.97	<0.0001	<0.0001	<0.0001	<0.0001
CK7+CD117+Claudin-7	0.75	1	<0.0001	<0.0001	<0.0001	<0.0001