Research Article
Geriatric Nutritional Risk Index Predicts Adverse Outcomes in Human Malignancy: A Meta-Analysis
Table 2
Stratification analysis for the meta-analysis with overall survival (OS) in patients with malignancies.
| Subgroup | No. of studies | No. of patients without risk | No. of patients at risk | Pooled HR (95% CI) | Heterogeneity | (%) | value |
| Altogether | 13 | 2,030 | 993 | 2.01 (1.49-2.71) | 85.0 | ≤0.001 | Publishing time | | | | | | | ≥2018 | 10 | 1,565 | 811 | 1.86 (1.38-2.51) | 84.4 | ≤0.001 | <2018 | 3 | 465 | 182 | 2.21 (1.31-3.75) | 69.3 | 0.021 | Country | | | | | | | Japan | 8 | 1,181 | 561 | 2.40 (1.86-3.10) | 44.7 | 0.081 | China | 5 | 849 | 432 | 1.43 (1.08-1.90) | 72.2 | 0.031 | Sample capacity | | | | | | | ≥240 | 7 | 1,355 | 742 | 1.45 (1.13-1.85) | 70.5 | 0.002 | <240 | 6 | 675 | 251 | 2.66 (2.00-3.55) | 42.6 | 0.107 | Dividing line for GNRI | | | | | | | ≥98 | 8 | 1,051 | 452 | 2.07 (1.41-3.03) | 86.9 | ≤0.001 | <98 | 5 | 979 | 541 | 1.84 (1.49-2.28) | 6.3 | 0.371 | Cancer system | | | | | | | Hematological | 5 | 646 | 539 | 2.02 (1.27-3.20) | 69.4 | 0.011 | Digestive | 6 | 992 | 366 | 1.74 (1.25-2.43) | 84.0 | ≤0.001 | Urinary | 1 | 273 | 66 | 1.80 (1.13-2.87) | — | — | Respiratory | 1 | 119 | 22 | 4.58 (2.36-8.88) | — | — | Primary therapy | | | | | | | Resection | 6 | 927 | 333 | 1.90 (1.25-2.88) | 88.6 | ≤0.001 | Chemotherapy | 4 | 615 | 507 | 1.97 (1.12-3.49) | 76.3 | 0.005 | Radiotherapy | 1 | 184 | 55 | 2.09 (1.32-3.30) | — | — | Others | 2 | 304 | 98 | 1.95 (1.33-2.86) | 0.0 | 0.552 | HR source | | | | | | | Crude | 9 | 1,587 | 841 | 1.78 (1.54-2.06) | 0.00 | 0.441 | Data | 4 | 443 | 152 | 2.71 (1.06-6.90) | 92.9 | ≤0.001 | Analytic method | | | | | | | Univariate | 5 | 596 | 215 | 2.62 (1.28-5.35) | 92.7 | ≤0.001 | Multivariate | 8 | 1,434 | 778 | 1.70 (1.46-1.99) | 0.0 | 0.590 |
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