Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease

Table 2

Frequency distribution of TMPRSS6 A736V, HFE C282Y, and HFE H63D gene variants (expressed as %) in two patient groups with IDA (sideropenic anemia) and ACD (ESRD patients).

Genotype/allele	Sideropenic anemia ()	ESRD patients ()
TMPRSS6 A736V
A/A	22.6	18.3	0.860
A/G	45.2	47.6
G/G	32.3	34.1
A allele	55.0	42.0	0.689
H-W (, )	0.241 (0.623)	0.07 (0.796)
HFE H63D
C/C	87.1	78.6	0.285
C/G	12.9	21.4
G/G	0	0
G allele	6.4	10.7	0.313
H-W (, )	0.147 (0.928)	1.808 (0.405)
HFE C282Y
G/G	93.5	95.2	0.720
G/A	6.5	4.8
A/A	0	0
A allele	3.2	2.4	0.143
H-W (, )	0.035 (0.982)	0.076 (0.962)
HFE haplotypes
wt/wt	0.81	0.74	0.546
C282Y/wt	0.06	0.05
H63D/wt	0.13	0.21