Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease

Table 4

Gender-related frequency distribution of TMPRSS6 A736V, HFE C282Y, and HFE H63D gene variants (%) in patients with ACD (ESRD patients).

Genotype/allele	Females ()	Males ()
TMPRSS6 A736V
A/A	14.8	20.8	0.653
A/G	48.1	47.2
G/G	37.0	31.9
A allele	39.0	44.0	0.377
H-W (, )	0.009 (0.923)	0.138 (0.710)
TMPRSS6 A736V (dominant model of inheritance)
G/G	37.0	31.9	0.551
A/G and A/A	63.0	68.1
HFE H63D
C/C	72.2	83.3	0.133
C/G	27.8	16.7
G/G	0	0
G allele	13.9	8.3	0.158
H-W (, )	1.407 (0.495)	0.598 (0.742)
HFE C282Y
G/G	94.4	95.8	0.717
G/A	5.6	4.2
A/A	0	0
A allele	2.8	2.1	0.720
H-W (, )	0.033 (0.984)	0.044 (0.977)
HFE Haplotypes
wt/wt	66.7	79.2	0.279
C282Y/wt	5.6	4.2
H63D/wt	27.8	16.7