Diet Alters Serum Metabolomic Profiling in the Mouse Model of Chronic Chagas Cardiomyopathy

Figure 1

T. cruzi infection altered body weights and glucose levels in chronic mice fed on different diets. (a) T. cruzi-infected HFD mice displayed greater body weight compared to infected RD-fed mice at 150 DPI. (b) T. cruzi infection increased the weights of the hearts compared to uninfected mice irrespective of the diets fed at 150 DPI. (c) The weights of the livers of HFD-fed mice (both uninfected and infected) were significantly increased compared to RD-fed (both uninfected and infected) mice. T. cruzi infection showed no significant effect on the weights of the livers. (d) Serum glucose measurements demonstrated that chronic T. cruzi infection has no significant effect on the levels of fasting glucose in RD-fed mice. However, the levels of fasting glucose significantly increased in infected HFD mice compared to infected RD-fed mice. (e) Infected HFD mice showed a better clearance of glucose during OGTT analysis compared to infected RD mice even though the basal levels of glucose were significantly greater in infected HFD mice compared to infected RD mice. The error bars represent standard error of the mean. , , or compared to uninfected RD mice. ^#, ^##, or ^### compared to infected RD mice. ^{^}, ^{^^}, or ^{^^^} compared to uninfected HFD mice. A bar represents the mean value in (a–c).

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