Diet Alters Serum Metabolomic Profiling in the Mouse Model of Chronic Chagas Cardiomyopathy
Table 2
A list of predicted metabolic biomarkers involved in the pathogenesis of CCM and RV and LV dilations in the murine models of chronic Chagas disease (arrows indicate decrease or increase).
Amino acids
CCM
RV
LV
Citrulline↓ Glutamine↓
Arginine↑ Asparagine↑
Amino derivative
Alpha-AAA↑ PEA↓ Spermidine↓
Sarcosine↑
Sarcosine↓
Carnitines
C9↓ C6:1↓ C14:1↓ C6 (C4:1-DC)↑
C16:OH↑ C16↓ C5-OH (C3-DC-M)↓
C12↑ C16↑ C16:1↑ C18:1↑ C18:1OH↑ C5-OH (C3-DC-M)↑
Sphingolipids
SM(OH)C14:1↓ SM C16:1↓
SM C20:2↑
SM C20:2↓
lysoPC
lysoPC a C18:1↓ lysoPC a C18:2↓ lysoPC a C20:3↓ lysoPC a C28:1↓
