Transcriptome Analysis of Hypertrophic Heart Tissues from Murine Transverse Aortic Constriction and Human Aortic Stenosis Reveals Key Genes and Transcription Factors Involved in Cardiac Remodeling Induced by Mechanical Stress

Table 2

GO items of the 16 shared DEGs with the same trends during the late stage of cardiac remodeling.

Term	Count	%	value	Genes
GO:0071260~cellular response to mechanical stimulus	4	25		NPPB, COL1A1, ANKRD1, NPPA
GO:0071560~cellular response to transforming growth factor beta stimulus	3	18.75		POSTN, COL1A1, ANKRD1
GO:0035582~sequestering of BMP in extracellular matrix	2	12.5		NBL1, FBN1
GO:0071356~cellular response to tumor necrosis factor	3	18.75		POSTN, COL1A1, ANKRD1
GO:0030308~negative regulation of cell growth	3	18.75		NPPB, FLCN, NPPA
GO:0007168~receptor guanylyl cyclase signaling pathway	2	12.5		NPPB, NPPA
GO:0061049~cell growth involved in cardiac muscle cell development	2	12.5		NPPB, NPPA
GO:0001666~response to hypoxia	3	18.75		NPPB, POSTN, NPPA
GO:0003085~negative regulation of systemic arterial blood pressure	2	12.5		NPPB, NPPA
GO:0006182~cGMP biosynthetic process	2	12.5		NPPB, NPPA