Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer

Figure 2

The receiver operating characteristic (ROC) curves were plotted for the biomarkers. (a) The ROC curve for ITIH₃ (area under the curve ). (b) The ROC curve for ITIH₄ (). (c) The ROC curve for CEA (). (d) The ROC curve for TIMP-1 (). (e) The diagnostic accuracy of ITIH₃ and ITIH₄ combinations was assessed by a logistic regression model. The ROC curve for combined ITIH₃ and ITIH₄ (). (f) The combinations of CEA, TIMP-1, ITIH₃, and ITIH₄ yielded the highest diagnostic accuracy ().

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