Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer

Figure 3

The expressions of ITIH₃ or ITIH₄ in human CRC tissues and their adjacent normal colorectal tissues were analyzed by immunohistochemical (IHC) staining. (a) The expressions of ITIH₃ in CRC tissues and the normal colorectal tissues. The boxed areas lined with black color in the left images of (a, b) were magnified in the middle and right ones. N: adjacent normal tissue (shown in the right column); C: CRC tissue (shown in the middle column). Original magnification, ×100-fold. (b) The expressions of ITIH₄ in CRC tissues compared with the normal colorectal tissues. (c) The IHC scores of the expressions for ITIH₃ and ITIH₄; the values were acquired by paired -test. (d, e) The individual line plot diagrams described the IHC scores of ITIH₃ and ITIH₄ expressions.

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