Research Article
Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer
Table 4
The ROC curves for differentiating CRC patients from healthy subjects.
| | Biomarker | No. of cases (CRC patients/controls) | AUC (95% CI) | Cutoff value | Sensitivity | Specificity | value |
| | ITIH3 | 101/156 | 0.638 (0.571-0.704) | 4.441 (μg/mL) | 0.679 | 0.525 | | | ITIH4 | 101/156 | 0.801 (0.745-0.857) | 0.170 (μg/mL) | 0.782 | 0.763 | | | CEA | 101/156 | 0.816 (0.754-0.878) | 3.515 (ng/mL) | 0.633 | 0.897 | | | TIMP-1 | 101/156 | 0.832 (0.776-0.888) | 205.680 (μg/mL) | 0.723 | 0.878 | | | ITIH3+ITIH4 | 101/156 | 0.827 (0.776-0.877) | 0.674 | 0.763 | 0.851 | | | ITIH3+ITIH4+CEA+TIMP-1 | 101/156 | 0.962 (0.940-0.985) | 0.705 | 0.917 | 0.908 | |
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: statistically significant. CRC: colorectal cancer; ITIH 3: inter-alpha-trypsin inhibitor heavy chain H3; ITIH 4: inter-alpha-trypsin inhibitor heavy chain H4; CEA: carcinoembryonic antigen; TIMP-1: tissue inhibitor of metalloproteinase-1. |
