Circulating MicroRNAs as Novel Potential Biomarkers for Left Ventricular Remodeling in Postinfarction Heart Failure

Figure 6

Target genes of plasma miR-20a-5p, miR-340-5p, and let-7i-5p. (a) Hierarchical clustering of 36 DE mRNAs ( or >2; ) in the 8-week post-MI group () compared with the sham group (). (b) The number and overlap among the downregulated mRNAs generated from mRNA sequencing and the predicted target genes of miR-20a-5p, miR-340-5p, and let-7i-5p. (c) The common genes among the downregulated genes, the target genes of miR-20a-5p, and the target genes of let-7i-5p. (d) The expression levels of Ddit4, Sesn1, and Nfkbia mRNAs in the validated 8-week post-MI group () compared with the corresponding sham group (), which were examined with real-time PCR. versus the sham group. DE: differentially expressed; mRNA: messenger RNA; MI: myocardial infarction; FC: fold change; TG: target genes; Ddit4: DNA-damage-inducible transcript 4; Sesn1: sestrin 1; Nfkbia: NF-κB inhibitor α.

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