The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

Table 2

Meta-analysis of circulating betatrophin levels and obesity by study characteristic.

Characteristic	No. of studies	Case	Control	WMD	(95% CI)	Heterogeneity tests
Geographic region
Europe	4	215	147	-18.76	(-37.049, -0.465)	0.96
Asia	3	111	116	1.16	(-2.579, 4.891)	0.096
Other	2	48	44	1.11	(-1.522, 3.744)	0.99
Sample source
Serum	6	198	157	-9.972	(-25.131, 5.187)	0.955
Plasma	3	176	150	0.172	(-0.123, 0.467)	0.878
Mean BMI (kg/m^2)
<35	3	111	116	1.16	(-2.579, 4.891)	0.096
≥35	5	234	167	-2.408	(-4.114, -0.703)	0.96
Unknown	1	29	24	2.460	(2.015, 2.905)	0.00
ELISA kit
Wuhan EIAAB Science Co.	3	110	126	0.541	(-0.077, 1.158)	0.946
Other	6	264	181	-10.478	(-24.627, 3.67)	0.948
Mean age
≥45	6	230	222	-7.656	(-11.645, -3.667)	0.955
<45	2	49	37	-0.224	(-0.521, 0.074)	0.465
Unknown	1	95	48	0.270	(0.244, 0.296)	0.0
Glycemic status
NG	5	215	176	0.534	(-0.313, 1.380)	0.92
Hyperglycemia	3	64	83	-18.547	(-37.148, 0.054)	0.88
Unknown	1	95	48	0.270	(0.244, 0.296)	0.00