Research Article

Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer

Figure 2

Intensity differences of TIGIT (green) and PD-1 (red) expression in (a) CD4+ helper T cells, (b) CD8+ cytotoxic T cells, and (c) FOXP3+ regulatory T cells between the interfollicular area (Ia), the marginal zone (Mz), the germinal centre periphery (Gcp), and the germinal centre (Gcc) of human tonsils. Relative expression refers to the fluorescence measurement in the tonsil germinal centre periphery set to 100%. Columns indicate the relative expression levels of TIGIT (green) and PD-1 (red). The black bar shows the TIGIT : PD-1 expression ratio.