High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype

Table 3

Univariate and multivariate analyses of prognostic factors for overall survival in CRC patients.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Gender
Male vs. female	1.591	0.966-2.619	0.068	NA
Age
≤60 vs. >60	1.008	0.0.617-1.648	0.973	NA
Tumor location
Right colon vs. left colon vs. rectum	1.038	0.773-1.393	0.806	NA
Differentiation
Poor vs. well and middle	0.533	0.177-1.607	0.264	NA
TNM stage
0 and I vs. II vs. III vs. IV	2.023	1.532-2.672	<0.001	0.980	0.469-2.050	0.958
T stage
Tis, T1, and T2 vs. T3 and T4b	3.398	1.692-6.825	0.001	2.079	0.726-5.951	0.173
N stage
N0 vs. N1a vs. N1b vs. N2a and N2b	1.493	1.207-1.847	<0.001	1.044	0.734-1.486	0.809
M stage
M0 vs. M1	5.983	3.244-11.036	<0.001	1.986	0.665-5.934	0.219
Preoperative CEA (ng/ml)
≤5 vs. >5	1.241	0.930-1.657	0.142	NA
LTBP2 expression
Low and none vs. high	23.619	13.036-42.794	<0.001	21.056	11.274-39.326	<0.001

Abbreviation: HR, hazard ratio; CI, confidence interval: NA, not considered in the multivariable model.