The Expression Patterns and Associated Clinical Parameters of Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 and Transmembrane and Immunoglobulin Domain Containing 2 in Oral Squamous Cell Carcinoma

Figure 1

HHLA2 was overexpressed, while the TMIGD2 expression level was decreased in oral squamous cell carcinoma. (a) Hematoxylin and eosin (HE) staining and HHLA2 as well as TMIGD2 immunostaining of oral mucosa and oral squamous cell carcinoma. Scale bar: 50 μm. (b) Continuously and significantly increased levels of HHLA2 expression from oral mucosa (MUC, ) to dysplasia (DYS, ) to OSCC (OSCC, ). All data are presented as the error of the mean and analyzed by one-way ANOVA with Tukey’s post hoc test. ; ; ; . (c) Continuously and significantly increased levels of TMIGD2 expression from oral mucosa (MUC, ) to dysplasia (DYS, ) to OSCC (OSCC, ). (d) The overall survival rate of the group of patients with lower HHLA2 expression () was significantly different from that of the group of patients with higher HHLA2 expression (, , ). (e) The overall survival rate of the group of patients with lower TMIGD2 expression () was significantly different from that of the group of patients with higher TMIGD2 expression (, ; the median expression of TMIGD2 was used as the cutoff).

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