Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease

Figure 2

Urine 5MedC and CKD outcome. Kaplan-Meier curves showing the renal endpoint-free survival categorized by urine 5MedC (μmol/gCr) and its combination with albuminuria (mg/gCr) (a) or urine α1MG (mg/gCr) (b). The combination of urine 5MedC with albuminuria (a) or urine α1MG (b) clearly separated the three-year renal endpoint-free survival of CKD patients. (a) and , ; and or and , ; and and , . (b) and , ; and or and , ; and , . indicates , n.s. denotes not significant. Log-rank test. UAE: urinary albumin excretion; uα1MG: urinary alpha1-microglobulin; u5MedC: urinary 5-methyl-2-deoxycytidine.

(a)

(b)