RAD51B (rs8017304 and rs2588809), TRIB1 (rs6987702, rs4351379, and rs4351376), COL8A1 (rs13095226), and COL10A1 (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration
Table 3
RAD51B (rs8017304 and rs2588809), TRIB1 (rs4351379), and COL8A1 (rs13095226) SNPs in patients with early and exudative AMD and control groups.
Gene/marker
Genotype/allele
Early AMD, (%)
Control group, (%)
value
Exudative AMD, (%)
Control group, (%)
value
RAD51B rs8017304
AA
125 (49.2)
451 (47.9)
117 (48.0)
451 (47.9)
AG
102 (40.2)
401 (42.6)
0.745
110 (45.1)
401 (42.6)
0.423
GG
27 (10.6)
90 (9.6)
17 (7.0)
90 (9.6)
A
352 (69.3)
1303 (69.2)
0.955
544 (70.5)
1303 (69.2)
G
156 (30.7)
581 (30.8)
144 (29.5)
581 (30.8)
0.570
RAD51B rs2588809
CC
196 (77.2)
740 (78.6)
188 (77.0)
740 (78.6)
CT
50 (19.7)
185 (19.6)
0.410
53 (21.7)
185 (19.6)
0.652
TT
8 (3.1)
17 (1.8)
3 (1.2)
17 (1.8)
C
442 (87.0)
1665 (88.4)
0.398
429 (87.9)
1665 (88.4)
T
66 (13.0)
219 (11.6)
59 (12.1)
219 (11.6)
0.775
TRIB1 rs4351379
GG
214 (84.3)
826 (87.7)
217 (88.9)
826 (87.7)
GC
39 (15.4)
109 (11.6)
0.229
26 (10.7)
109 (11.6)
0.780
CC
1 (0.4)
7 (0.7)
1 (0.4)
7 (0.7)
G
467 (91.9)
1761 (93.5)
0.222
460 (94.3)
1761 (93.5)
C
41 (8.1)
123 (6.5)
28 (5.7)
123 (6.5)
0.524
COL8A1 rs13095226
TT
166 (65.4)
611 (64.9)
147 (60.2)
611 (64.9)
TC
74 (29.1)
304 (32.3)
0.095
82 (33.6)
304 (32.3)
0.036
CC
14 (5.5)
27 (2.9)
15 (6.1)
27 (2.9)
T
406 (79.9)
1526 (81.0)
0.585
376 (77.0)
1526 (81.0)
C
102 (20.1)
358 (19.0)
112 (23.0)
358 (19.0)
0.051
AMD: age-related macular degeneration. value < 0.05 indicated in bold is statistically significant.
