Identification of METTL14 in Kidney Renal Clear Cell Carcinoma Using Bioinformatics Analysis

Figure 3

The potential mechanism of METTL14 in KIRC. (a) The relevance between METTL14 mRNA expression and the mutation rate of 9 hub genes in KIRC. (b) The expression of PTEN mRNA and METTL14 mRNA in KIRC had a significantly positive correlation. (c) The m6A motif base sequence in which METTL14 binds to mRNA was more likely to be GGACU (RMBase v2.0). (d) The m6A motif base sequence was located in the junction between CDS and 3UTR of mRNA with higher probability. The location of GGACU sequence in PTEN mRNA. (e) (A) The expression level of EIF3A mRNA had significantly differential expression in KIRC versus normal tissues. (B) The expression of EIF3A mRNA and PTEN mRNA in KIRC had a significantly positive correlation. (C, D) The TCGA survival analysis for EIF3A.

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