Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma

Table 2

Receiver operating characteristic curve analyses showing the utility of alone or combined markers for differentiating of LC and HCC.

Marker	Sensitivity	Specificity	PPV	NPV	AUC
Zonulin (ng/ml)	0.922	0.889	0.892	0.920	0.942 (0.898-0.972)
AFP (ng/ml)	0.789	0.656	0.696	0.756	0.797 (0.731-0.854)
Zonulin+AFP	0.878	0.978	0.878	0.978	0.967 (0.929-0.988)

PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.