Comparing MicroRNA Profilings of Purified HER-2-Negative and HER-2-Positive Cells Validates miR-362-5p/Sema3A as Characteristic Molecular Change in Triple-Negative Breast Cancers

Table 2

Univariate and multivariate Cox proportional hazard models for OS.

	Overall survival (OS)
	Univariate		Multivariate
	HR (95% CI)		HR (95% CI)
Age
≤50y	1
>50y	1.597 (0.870-2.931)	0.131
Grade
I+II	1
III	1.085 (0.572-2.057)	0.802
T stage
T1	0.239 (0.088-0.644)	0.005
T2	0.424 (0.198-0.908)	0.027
T3	1
N stage
N0	0.272 (0.113-0.652)	0.004
N1	0.351 (0.136-0.907)	0.031
N2	0.466 (0.163-1.331)	0.154
N3	1
AJCC stage
I	0.340 (0.126-0.916)	0.033	0.466 (0.167-1.302)	0.145
II	0.363 (0.189-0.699)	0.002	0.458 (0.231-0.909)	0.025
III	1		1
HER-2
Negative	1
Positive	1.300 (0.708-2.386)	0.397
ER
Negative	2.060 (1.104-3.844)	0.023	1
Positive	1		1.976 (1.020-3.829)	0.044
PR
Negative	1.749 (0.898-3.407)	0.1
Positive	1
Types
ER^+ and/or PR^+	1
HER-2^+/ER^−/PR^−	1.902 (0.878-4.122)	0.103
HER-2^−/ER^−/PR^−	2.122 (1.055-4.269)	0.035
miR-362-5p
Negative/weak	1.873 (1.010-3.471)	0.046
Moderate/strong	1
Sema3A
Negative/weak	1		1
Moderate	4.716 (1.773-12.547)	0.002	3.723 (1.221-11.353)	0.021
Strong	3.619 (1.343-9.752)	0.011	3.966 (1.333-11.803)	0.013