Disease Markers

Research Article

ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease

Table 2

Information of clinical characteristics and laboratory data in the NCAD group and the CAD group.
CharacteristicsNCAD ()CAD ()
Gender (M/F)20/1678/450.438
Age (years)63 (51, 74)64 (57, 73)0.465
Smoking (, %)6 (16.7%)38 (30.9%)0.137
Drinking (, %)2 (5.56%)22 (17.9%)0.110
Hypertension (, %)25 (69.4%)95 (77.2%)0.380
Hyperlipidemia (, %)14 (38.9%)39 (31.7%)0.428
Diabetes (, %)7 (19.4%)39 (31.7%)0.210
Glu (mmol/L)5.33 (4.84, 5.68)5.53 (4.93, 6.45)0.119
SBP (mmHg)147 (139, 155)144 (127, 158)0.627
DBP (mmHg)80 (74, 93)82 (74, 90)0.818
HDL-C (mmol/L)1.06 (0.87, 1.28)1.00 (0.83, 1.22)0.548
LDL-C (mmol/L)2.20 (1.89, 2.54)2.03 (1.50, 2.58)0.174
TC (mmol/L)4.16 (3.65, 5.04)4.10 (3.34, 4.83)0.338
TG (mmol/L)1.38 (1.18, 1.82)1.45 (0.97, 2.23)0.951
CRP (mg/L)0.94 (0.43, 2.06)4.04 (1.78, 10.4)<0.001
ADAMTS-5 (ng/mL)7.62 (5.60, 10.5)4.64 (3.02, 6.41)<0.001
MMP-2 (ng/mL)7.95 (5.06, 12.4)13.3 (9.09, 17.6)<0.001
MMP-9 (ng/mL)50.1 (34.8, 78.9)83.4 (59.0, 103.4)<0.001
Gensini score—24 (10, 46)—
Medications, (%)   
 Aspirin13 (36.1%)62 (50.4%)0.184
 Statin8 (22.2%)47 (38.2%)0.110
 ACEI/ARB17 (47.2%)66 (53.6%)0.571
 CCB11 (30.5%)52 (42.3%)0.247
 β-Receptor blockers6 (16.7%)35 (28.5%)0.196
 Diuretic3 (8.33%)7 (5.69%)0.696
 Insulin4 (11.1%)22 (17.8%)0.446
 Oral hypoglycemics2 (5.56%)17 (13.8%)0.248
Data are expressed as median (interquartile range) or the number (percentage) for category variables. Glu: fasting glucose; SBP: systolic blood pressure; DBP: diastolic blood pressure; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TC: total cholesterol; TG: total triglycerides; CRP: C-reactive protein; ADAMTS-5: a disintegrin and metalloproteinase with thrombospondin type 1 motif-5; MMP-2: matrix metalloproteinase-2; MMP-9: matrix metalloproteinase-9; ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; CCB: calcium channel blockers.