PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer

Figure 4

Western blotting analysis of expression of P53-nf (nuclear fraction of P53 and P53-nf), P53-cf (cytoplasmic fraction of P53 and P53-cf), cleaved caspase-3, and caspase-3 in PCDHGB7-overexpressing Hs578T and BT549 cells. PCDHGB7 protein is overexpressed in Hs578T cells (a, b) and BT549 cells (c, d). Cytoplasmic P53 (P53-cf) is significantly reduced, and nuclear P53 (P53-nf), cleaved caspase-3, and caspase-3 are elevated. Data are presented as the from three independent experiments (, , and ).

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