PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer

Figure 5

Western blotting analysis of P53-nf (nuclear fraction of P53 and P53-nf), P53-cf (cytoplasmic fraction of P53 and P53-cf), cleaved caspase-3, and caspase-3 expression in Hs578T and BT549 cells with PCDHGB7 knockdown. PCDHGB7 was knocked down in Hs578T cells (a, b) and BT549 cells (c, d). Nuclear P53 (P53-nf), cleaved caspase-3, and caspase-3 levels were significantly reduced, and cytoplasmic P53 (P53-cf) is elevated. Data are presented as the from three independent experiments. Representative WB images are presented in the top panel (, , and ).

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