PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer

Figure 7

Western blotting analysis of P53-nf (nuclear fraction of P53), P53-cf (cytoplasmic fraction of P53), cleaved caspase-3, and caspase-3 in Hs578T and BT549 cells with HSPA9 knockdown. (a, b) P53-cf is significantly reduced in HSPA9-knocked down Hs578T cells, whereas P53-nf and cleaved caspase-3 are elevated. (c, d) P53-cf is decreased, whereas P53-nf, cleaved caspase-3, and caspase-3 are elevated in BT549 cells. Data are presented as the from three independent experiments. Representative WB images are presented in the top panel (, , and ).

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