Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer

Table 4

Univariate and multivariate Cox analysis of variables considered for progression-free survival rates of breast cancer patients.

Variables	Category	Univariate analysis			Multivariate analysis
		HR	95% CI	value	HR	95% CI	value
Age	≤45 Y vs. >45 Y	1.41	0.71-2.74	0.38	1.34	0.69-2.36	0.43
Menopausal status	Post vs. pre	2.13	1.095-3.67	0.02	2.11	1.42-4.05	0.03
ER status	Negative vs. positive	1.79	1.06-4.53	0.04	2.45	1.12-4.61	0.02
PR status	Negative vs. positive	1.17	0.79-2.12	0.38	1.33	0.72-2.18	0.29
HER2 status	Positive vs. negative	1.95	0.92-4.33	0.09	1.87	0.83-4.04	0.11
Size	>2 cm vs. ≤2 cm	2.91	1.68-5.87	0.003	1.91	0.91-4.34	0.09
Lymph node status	Positive vs. negative	4.15	1.85-7.03	<0.001	2.72	1.51-5.95	0.002
TNM stage	III vs. I+II	2.27	1.17-3.79	0.03	2.67	1.27-5.72	0.004
Serum sFRP2	>58.0 vs. ≤58.0 ng/mL	4.14	2.07-8.78	<0.001	3.89	1.95-7.68	0.001

Abbreviations: HR: hazard ratio; CI: confidence interval; Y: years; ER status: estrogen receptor status; PR status: progesterone receptor status; HER2 status: human epidermal growth factor receptor 2 status. value < 0.05, statistically significant.