Disease Markers / 2019 / Article / Tab 4

Research Article

Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer

Table 4

Univariate and multivariate Cox analysis of variables considered for progression-free survival rates of breast cancer patients.

VariablesCategoryUnivariate analysisMultivariate analysis
HR95% CI valueHR95% CI value

Age≤45 Y vs. >45 Y1.410.71-2.740.381.340.69-2.360.43
Menopausal statusPost vs. pre2.131.095-3.670.022.111.42-4.050.03
ER statusNegative vs. positive1.791.06-4.530.042.451.12-4.610.02
PR statusNegative vs. positive1.170.79-2.120.381.330.72-2.180.29
HER2 statusPositive vs. negative1.950.92-4.330.091.870.83-4.040.11
Size>2 cm vs. ≤2 cm2.911.68-5.870.0031.910.91-4.340.09
Lymph node statusPositive vs. negative4.151.85-7.03<0.0012.721.51-5.950.002
TNM stageIII vs. I+II2.271.17-3.790.032.671.27-5.720.004
Serum sFRP2>58.0 vs. ≤58.0 ng/mL4.142.07-8.78<0.0013.891.95-7.680.001

Abbreviations: HR: hazard ratio; CI: confidence interval; Y: years; ER status: estrogen receptor status; PR status: progesterone receptor status; HER2 status: human epidermal growth factor receptor 2 status. value < 0.05, statistically significant.

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