Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients
Table 1
Basic characteristics and HNF1A SNP distribution frequencies by gender among healthy Chinese subjects.
Total population
Men
Women
Sex ()
1010
615
395
—
Age (years)
0.488
BMI (kg/m2)
<0.001
Systolic pressure (mmHg)
0.001
Diastolic pressure (mmHg)
<0.001
LDL (mmol/l)
0.864
HDL (mmol/l)
<0.001
TC (mmol/l)
0.014
AST (U/l)
20.40 (17.40, 24.80)
21.60 (18.70, 26.00)
18.80 (16.50, 22.40)
<0.001
FPG (mmol/l)
0.019
ALT (U/l)
18.50 (13.10, 26.83)
21.50 (15.50, 29.80)
14.40 (10.10, 20.30)
<0.001
TG (mmol/l)
1.27 (0.88, 1.89)
1.46 (1.02, 2.07)
1.04 (0.75, 1.53)
<0.001
GGT (U/l)
21.50 (14.78, 35.73)
27.50 (19.00, 41.70)
15.10 (11.90, 20.90)
<0.001
CRP (mg/l)
1.08 (0.68, 1.81)
1.18 (0.79, 2.03)
0.85 (0.53, 1.52)
<0.001
AFP (ng/ml)
3.61 (2.69, 4.70)
3.48 (2.61, 4.67)
3.07 (2.84, 4.70)
0.158
Fatty liver (%)
44.7
56.1
26.8
<0.001
rs1169288
AA
311 (30.8%)
189 (30.7%)
122 (30.9%)
0.997
AC
483 (47.8%)
294 (47.8%)
189 (47.8%)
CC
216 (24.4%)
132 (21.5%)
84 (21.3%)
rs2464196
GG
290 (28.7%)
173 (28.1%)
117 (29.6%)
0.355
GA
473 (46.8%)
282 (45.9%)
191 (48.4%)
AA
247 (24.5%)
160 (26.0%)
87 (22.0%)
rs1169310
CC
282 (27.9%)
166 (27.0%)
116 (29.4%)
0.327
CT
478 (47.3%)
287 (46.7%)
191 (48.4%)
TT
250 (24.8%)
162 (26.3%)
88 (22.3%)
Data are presented as the or (%). Nonnormally distributed data are presented as the median (interquartile range (IQR)). The TG, CRP, ALT, AST, GGT, and AFP data were ln-transformed before analysis. value indicates the comparison of male vs. female using independent-sample -test for continuous variables and using Chi-squared test for categorical variables and SNP distribution frequencies.
