Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients

Table 4

Association of rs2464196 and rs1169310 genotypes with AFP level in Chinese HCC patients.

	rs2464196					rs1169310
		β	95% CI	SE			β	95% CI	SE
Model 1	0.037	-1.040	-1.767, -0.314	0.368	0.005260	0.047	-1.179	-1.915, -0.444	0.373	0.001827
Model 2	0.256	-0.964	-1.633, -0.294	0.339	0.005012	0.265	-1.099	-1.778, -0.420	0.344	0.001665
Model 3	0.586	-0.530	-1.041, -0.018	0.259	0.042404	0.587	-0.576	-1.100, -0.053	0.265	0.031127

Model 1: no adjustment; model 2: adjusted for age and gender, lnALT, lnAST, and HBV and HCV infection status; model 3: adjusted for age, gender, lnALT, lnAST, HBV and HCV infection status, tumor size, clinical stage, and differentiation degree. β represents the unstandardized beta coefficients (β) for the effects of HNF1A polymorphisms on the AFP levels. value for the association of rs2464196 or rs1169310 genotypes with AFP level. values that passed Bonferroni correction ().