Review Article
The Prognostic Role of Klotho in Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis
Table 1
Characteristics of the included studies.
| First author | Year | Country | Study design | Number | Follow-up period | Average age | Average eGFR(ml/min) | Low versus high sKlotho level | Outcomes | HR and 95% CI |
| Liu (Ref [25]) | 2018 | China | Cross-sectional Prospective | 112 | months | |
| Median sKlotho level | Scr doubling RRT Death | Direct | Bob (Ref [21]) | 2018 | Romania | Cross-sectional Retrospective | 63 | 12 months | | | Overall sKlotho | Δdecline of eGFR | — | Fountoulakis (Ref [23]) | 2018 | UK | Cross-sectional Prospective | 101 | 9 (2-13) years | 60 (40-82) | | Median sKlotho level | 50% decline of eGFR Death | Indirect (estimated HR) | Qian (Ref [16]) | 2018 | China | Cross-sectional Prospective | 112 | 1.5 years | | — | ΔsKlotho level | RRT Cardio-cerebrovascular events | — | Drew (Ref [22]) | 2017 | America | Prospective | 2496 | 3 or 10 years | | | sKlotho quartile level | eGFR or >3 ml/min per year | Indirect (estimated OR) | Kim (Ref [24]) | 2017 | Korea | Prospective | 147 | 32 (12-52) months | | | sKlotho tertile level | Annual eGFR decline Albuminuria | Direct | Kim (Ref [13]) | 2013 | Korea | Cross-sectional Prospective | 243 | 29.7 (6.0-62.1) months | | | Median sKlotho level | Scr doubling RRT Death | Direct | Seiler (Ref [18]) | 2013 | Germany | Cross-sectional Prospective | 312 | years | | | sKlotho tertile level | RRT Death | Direct |
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Abbreviation: RRT: renal replacement therapy; Scr: serum creatinine; HRs: hazard ratios; CI: confidence interval; eGFR: estimated glomerular filtration rate; Ref: reference.
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