Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure
Table 3
Distribution of GSTA1, GSTP1, GSTM1, and GSTT1 genotypes in HF patients and controls.
Genotype
Controls ( (%))
HF patients ( (%))
OR (95% CI)a
GSTA1
A/A
112 (41)
68 (35)
1.0b
A/B+B/B
162 (59)
125 (65)
1.5 (0.9-2.5)
0.097
GSTP1Ile105Val (rs1695)
Ile/Ile
115 (42)
68 (35)
1.0b
Ile/Val+Val/Val
159 (58)
124 (65)
1.7 (1.0-2.9)
0.031
GSTM1
Active
137 (50)
92 (47)
1.0b
Null
137 (50)
102 (53)
1.1 (0.7-1.8)
0.671
GSTT1
Active
203 (74)
146 (74)
1.0b
Null
71 (26)
48 (26)
0.9 (0.5-1.7)
0.873
Combined GSTA1/ GSTP1(rs1695)
AA/IleIle
54 (20)
29 (16)
1.0b
AA/IleVal+ValVal
58 (21)
39 (20)
1.2 (0.5-2.6)
0.697
AB+BB/IleIle
61 (22)
39 (20)
1.0 (0.5-2.3)
0.913
AB+BB/IleVal+ValVal
101 (37)
84 (44)
2.2 (1.1-4.4)
0.034
GST genotype/smoking status
Controls ( (%))
Bladder cancerpatients ( (%))
OR (95% CI)c
GSTM1-active/nonsmoker
50 (46)
16 (18)
1.00b
GSTM1-null/smoker
58 (54)
75 (82)
4.4 (2.2-8.9)
<0.001
HF: heart failure; CI: confidence interval; OR: odds ratio. aLogistic regression to compute odds ratios (ORs)adjusted for gender, age, smoking, hypertension, and diabetes. bReference group. cLogistic regression to compute odds ratios adjusted for gender, age, and body mass index. Statistically significant in comparison with the reference genotype ().
