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Research Article

Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure

Table 3

Distribution of GSTA1, GSTP1, GSTM1, and GSTT1 genotypes in HF patients and controls.

GenotypeControls ( (%))HF patients ( (%))OR (95% CI)a

GSTA1
A/A112 (41)68 (35)1.0b
A/B+B/B162 (59)125 (65)1.5 (0.9-2.5)0.097
GSTP1Ile105Val (rs1695)
Ile/Ile115 (42)68 (35)1.0b
Ile/Val+Val/Val159 (58)124 (65)1.7 (1.0-2.9)0.031
GSTM1
 Active137 (50)92 (47)1.0b
 Null137 (50)102 (53)1.1 (0.7-1.8)0.671
GSTT1
 Active203 (74)146 (74)1.0b
 Null71 (26)48 (26)0.9 (0.5-1.7)0.873
Combined GSTA1/ GSTP1(rs1695)
AA/IleIle54 (20)29 (16)1.0b
AA/IleVal+ValVal58 (21)39 (20)1.2 (0.5-2.6)0.697
AB+BB/IleIle61 (22)39 (20)1.0 (0.5-2.3)0.913
AB+BB/IleVal+ValVal101 (37)84 (44)2.2 (1.1-4.4)0.034
GST genotype/smoking statusControls ( (%))Bladder cancerpatients ( (%))OR (95% CI)c
GSTM1-active/nonsmoker50 (46)16 (18)1.00b
GSTM1-null/smoker58 (54)75 (82)4.4 (2.2-8.9)<0.001

HF: heart failure; CI: confidence interval; OR: odds ratio. aLogistic regression to compute odds ratios (ORs)adjusted for gender, age, smoking, hypertension, and diabetes. bReference group. cLogistic regression to compute odds ratios adjusted for gender, age, and body mass index. Statistically significant in comparison with the reference genotype ().

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