Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure

Table 6

Markers of oxidative stress, inflammation, and endothelial dysfunction in CAD-related HF patients stratified according to GST genotypes.

Genotype	MDA (μmol/L)^a	hs-CRP (mg/L)^b	TNFα (pg/mL)^b	ICAM-1 (ng/L)^b	VCAM-1 (ng/L)^b
GSTA1
A/A		2.12 (0.49-43.51)	2.25 (0.15-47.63)	375.90 (206.43-696.91)	1113.12 (563.85-3697.45)
A/B+B/B		2.14 (0.15-45.00)	2.25 (0.22-29.76)	380.98 (264.20-691.04)	1063.23 (144.45-7429.55)
	0.802	0.600	0.792	0.526	0.505
GSTP1 (rs1695)
Ile/Ile		1.91 (0.38-35.68)	2.15 (0.33-11.12)	363.38 (206.43-553.84)	1152.30 (563.85-1793.90)
Ile/Val+Val/Val		2.29 (0.15-45.00)	2.34 (0.15-47.63)	390.10 (255.12-696.91)	1095.20 (144.45-7429.55)
	0.745	0.382	0.557	0.041	0.882
GSTP1 (rs1138272)
Ala/Ala		2.14 (0.15-45.00)	2.21 (0.15-11.12)	381.25 (206.43-696.91)	1109.25 (144.45-7429.55)
Ala/Val+Val/Val		2.08 (0.93-43.51)	4.69 (0.63-47.63)	351.35 (275.60-568.10)	1040.95 (759.25-1871.55)
	0.436	0.777	0.045	0.152	0.899

MDA: malondialdehyde; hs-CRP: high-sensitivity C-reactive protein; TNFα: tumor necrosis factor-alpha; ICAM-1: intercellular adhesion molecule-1; VCAM-1: vascular cell adhesion molecule-1. ^aStudent t-test was used. ^bMann-Whitney test was used. Statistically significant at .