Disease Markers / 2019 / Article / Tab 6

Research Article

Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure

Table 6

Markers of oxidative stress, inflammation, and endothelial dysfunction in CAD-related HF patients stratified according to GST genotypes.

GenotypeMDA (μmol/L)ahs-CRP (mg/L)bTNFα (pg/mL)bICAM-1 (ng/L)bVCAM-1 (ng/L)b

GSTA1
A/A2.12 (0.49-43.51)2.25 (0.15-47.63)375.90 (206.43-696.91)1113.12 (563.85-3697.45)
A/B+B/B2.14 (0.15-45.00)2.25 (0.22-29.76)380.98 (264.20-691.04)1063.23 (144.45-7429.55)
0.8020.6000.7920.5260.505
GSTP1 (rs1695)
Ile/Ile1.91 (0.38-35.68)2.15 (0.33-11.12)363.38 (206.43-553.84)1152.30 (563.85-1793.90)
Ile/Val+Val/Val2.29 (0.15-45.00)2.34 (0.15-47.63)390.10 (255.12-696.91)1095.20 (144.45-7429.55)
0.7450.3820.5570.0410.882
GSTP1 (rs1138272)
Ala/Ala2.14 (0.15-45.00)2.21 (0.15-11.12)381.25 (206.43-696.91)1109.25 (144.45-7429.55)
Ala/Val+Val/Val2.08 (0.93-43.51)4.69 (0.63-47.63)351.35 (275.60-568.10)1040.95 (759.25-1871.55)
0.4360.7770.0450.1520.899

MDA: malondialdehyde; hs-CRP: high-sensitivity C-reactive protein; TNFα: tumor necrosis factor-alpha; ICAM-1: intercellular adhesion molecule-1; VCAM-1: vascular cell adhesion molecule-1. aStudent t-test was used. bMann-Whitney test was used. Statistically significant at .

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