Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses

Figure 3

Orai2 differential expression analysis. The heat maps displaying the DEGs in the CLA, MES, (a, d) NEU, and (b, e) PRO subtypes of GBM. (c, f) Heat map displaying the DEGs between the Orai2^high and Orai2^low groups in CLA and MES GBM. (g) A comparison of the 3404, 7193, and 6056 genes revealed 806 common genes specific to the Orai2 that were correlated with the classical subgroup. (h) A comparison of the 3030, 6635, and 6606 genes revealed 851 common genes specific to the Orai2 that were correlated with the mesenchymal subgroup. (i) A comparison of the 806 and 851 genes revealed 185 common genes specific to Orai2 that were correlated between the classical and mesenchymal subgroups. C&N: the overlap between the classical and neural subtypes; C&P: the overlap between the classical and proneural subtypes; M&N: the overlap between the mesenchymal and neural subtypes; M&P: the overlap between the mesenchymal and proneural subtypes; OCGIC: Orai2-correlated genes in the classical GBM; OCGIM: Orai2-correlated genes in the mesenchymal GBM; GBM: glioblastoma; DEG: differentially expressed genes.

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