Prostatic Acid Phosphatase (PAP) Predicts Prostate Cancer Progress in a Population-Based Study: The Renewal of PAP?
Table 2
The multivariable logistic regression for the presence of metastases at diagnosis of prostate cancer.
Pt. no.
Multivariable logistic regression analysis Hazard Ratio (95% CI)
Localized
With invasion
With metastasis
Among pt. with invasion
value
Among pt. with metastasis
value
Age at diagnosis (y)
30-50
256
13
17
1 (Reference)
NA
1 (Reference)
NA
51-70
4217
185
283
0.86 (0.49-1.54)
0.62
1.01 (0.61-1. 68)
0.97
71-85
2438
125
325
1.01 (0.56-1.81)
0.97
2.01 (1.21-3. 32)
0.01
≥86
152
13
62
1.68 (0.76-3.73)
0.20
6.14 (3.46-10.89)
<0.01
Race
White
5303
238
478
1 (Reference)
NA
1 (Reference)
NA
Black
1184
79
157
1.49 (1.14-1.93)
<0.01
1.47 (1.22-1. 78)
<0.01
Asian
495
15
42
0.68 (0.40-1.15)
0.15
0.94 (0.68-1.31)
0.72
American Indian
21
4
8
4.24 (1.45-12.46)
0.01
4.23 (1.86-9.59)
<0.01
Grade
1
299
6
6
1 (Reference)
NA
1 (Reference)
NA
2
4880
139
146
1.42 (0.62-3.24)
0.41
1.49 (0.65-3.40)
0.34
3
1639
173
315
5.26 (2.31-11.98)
<0.01
9.58 (4.23-21.68)
<0.01
4
26
3
16
5.75 (1.36-24.33)
0.02
30.67 (11.06-85.07)
<0.01
Number of localized tumors
1
6218
304
648
1 (Reference)
NA
1 (Reference)
NA
≥2
845
32
39
0.81 (0.61-1.07)
0.13
0.74 (0.61-0. 91)
<0.01
PAP
-
2878
242
127
1 (Reference)
NA
1 (Reference)
NA
+
4185
94
560
1.78 (1.39-2.26)
<0.01
3.03 (2.49-3.70)
<0.01
The multivariable logistic regression was used to determine whether age and race were associated with the presence of invasion and metastases at diagnosis; other variables in the model included pathological grade and number of localized tumors. The likelihood ratio test (LRT) is used in the multivariable logistic regression analysis. Abbreviations: PAP: prostatic acid phosphatase; y: years; Pt. no.: patient number; ;.
