Prostatic Acid Phosphatase (PAP) Predicts Prostate Cancer Progress in a Population-Based Study: The Renewal of PAP?
Table 3
The multivariable Cox regression for all-cause mortality and prostate cancer-specific mortality among PCa patients and postsurgical dead.
All-cause mortality
Prostate cancer-specific mortality
Pt. no.
Hazard Ratio (95% CI)
value
Pt. no.
Hazard Ratio (95% CI)
value
Age at diagnosis (y)
30-50
292
1 (Reference)
NA
285
1 (Reference)
NA
51-70
4784
2.88 (1.84-4.51)
<0.01
4487
2.16 (1.24-3.77)
0.01
71-85
3009
7.57 (4.82-11.89)
<0.01
2662
6.09 (3.47-10.69)
<0.01
≥86
260
23.43 (14.17-38.73)
<0.01
228
17.34 (8.63-34.83)
<0.01
Race
White
6209
1 (Reference)
NA
5649
1 (Reference)
NA
Black
1473
1.33 (1.17-1.50)
<0.01
1386
1.46 (1.20-1.77)
<0.01
Asian
563
0.85 (0.72-1.01)
0.06
529
0.81 (0.63-1.05)
0.11
American Indian
35
2.00 (0.64-6.27)
0.24
34
1.25 (0.17-9.05)
0.82
2153
1 (Reference)
NA
1954
1 (Reference)
NA
2084
0.95 (0.86-1.05)
0.31
1927
0.96 (0.82-1.13)
0.64
737
0.59 (0.48-0.72)
<0.01
692
0.66 (0.49-0.89)
0.01
304
0.98 (0.76-1.26)
0.88
276
0.87 (0.59-1.28)
0.49
6409
1 (Reference)
NA
5898
1(Reference)
NA
38
2.85 (1.68-4.85)
<0.01
36
5.01 (2.65-9.46)
<0.01
27
1.50 (0.80-2.83)
0.21
25
3.10 (1.45-6.65)
<0.01
5
3.82 (1.41-10.32)
0.01
5
2.29 (0.32-16.53)
0.41
7424
NA
NA
6857
NA
NA
672
NA
NA
590
NA
NA
Grade
1
317
1 (Reference)
NA
281
1 (Reference)
NA
2
5249
0.79 (0.65-0.96)
0.02
4847
0.81 (0.60-1.10)
0.18
3
2209
1.20 (0.98-1.48)
0.08
2025
1.41 (1.03-1.92)
0.03
4
47
2.39 (1.20-4.73)
0.01
39
2.35 (0.83-6.68)
0.11
Number of localized tumors
1
6475
1 (Reference)
NA
6475
1 (Reference)
NA
≥2
1870
1.88 (1.71-2.06)
<0.01
1187
1.89 (1.62-2.21)
<0.01
Location
Localized
7063
1 (Reference)
NA
652
1 (Reference)
NA
Invasion
336
2.09 (1.64-2.66)
<0.01
1 311
2.21 (1.54-3.18)
<0.01
Metastasis
687
6.48 (3.42-12.30)
<0.01
606
9.52 (4.47-20.24)
<0.01
PAP
-
3161
1 (Reference)
NA
2879
1 (Reference)
NA
+
5184
1.04 (0.95-1.14)
0.42
4783
2.87 (2.48-3.32)
<0.01
Surgery
Y
2760
1 (Reference)
NA
2553
1 (Reference)
NA
N
5585
1.12 (1.00-1.26)
0.05
5109
1.09 (0.91-1.30)
0.36
The multivariable Cox regression was performed to identify covariates associated with increased all-cause mortality using the same variables as in the logistic regression model described. In the Cox regression model, enter method was used. Abbreviations: Pt. no.: patient number; y: years; TNM: tumor-node-metastasis; Y: yes; N: no; ;.
