Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population
Table 2
Allelic association of single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) with ischemic stroke (IS) in a pilot study.
SNP
Gene
Region
Allele
MAF
OR (95% CI)
Con (%)
Case (%)
rs243080
miRNA-4432
Pre-miRNA
A>G
29.7
28.9
0.96 (0.70-1.33)
0.82
rs10175383
miRNA-3679
Pre-miRNA
G>C
33.5
33.2
0.99 (0.72-1.35)
0.94
rs79402775
miRNA-933
Mature
G>A
13.8
19.3
1.50 (1.01-2.22)
0.044
rs4674470
miRNA-4268
Pre-miRNA
T>C
20.9
24.6
1.24 (0.87-1.76)
0.24
rs11714172
miRNA-4792
Pre-miRNA
G>T
47.1
50.0
1.12 (0.84-1.51)
0.44
rs12523324
miRNA-4277
Pre-miRNA
A>G
47.5
44.2
0.88 (0.65-1.18)
0.39
rs2910164
miRNA-146A
Seed
C>G
37.9
38.2
1.02 (0.75-1.38)
0.92
rs66683138
miRNA-3622A
Seed
G>A
41.9
35.0
0.78 (0.55-1.01)
0.06
rs35196866
miRNA-4669
Pre-miRNA
A>C
33.3
25.0
0.68 (0.48-0.93)
0.016
rs832733
miRNA-4698
Pre-miRNA
C>T
26.3
25.7
0.97 (0.70-1.36)
0.87
rs11614913
miRNA-196A2
Mature
T>C
45.6
46.8
1.05 (0.78-1.41)
0.75
rs2289030
miRNA-492
Pre-miRNA
G>C
18.4
16.8
0.86 (0.58-1.28)
0.47
rs61938575
miRNA-3922
Mature
G>A
17.7
18.3
1.04 (0.71-1.53)
0.83
rs12894467
miRNA-300
Pre-miRNA
T>C
21.5
24.6
1.20 (0.85-1.70)
0.31
rs56103835
miRNA-323B
Pre-miRNA
C>T
26.4
26.6
1.01 (0.73-1.42)
0.94
rs2620381
miRNA-627
Seed
A>C
10.6
13.4
1.30 (0.83-2.05)
0.25
rs8078913
miRNA-4520A
Mature
T>C
30.9
33.5
1.13 (0.82-1.54)
0.47
rs7207008
miRNA-2117
Pre-miRNA
T>A
28.7
35.4
1.36 (0.99-1.87)
0.055
rs3746444
miRNA-499A
Mature
A>G
16.0
15.7
0.98 (0.65-1.46)
0.91
Bold characters represent statistically significant values (). “Pre-miRNA” indicates other regions of pre-miRNA except mature miRNA sequences. “Mature” indicates the mature miRNA region excluding seed sequences. “Seed” indicates seed region, nucleotides 2 to 8 at the 5 end of the mature miRNA. CI: confidence interval; MAF: minor allele frequency; OR: odds ratio.
