Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation

Figure 4

INHBA blockade in SKOV3 causes xenograft tumor growth inhibition and reduces stroma activation in vivo. (a, b) Bright field images and weight quantification of subcutaneous tumors from mice () of the sh-Ctrl or sh-INHBA groups. (c) Representative IHC images of INHBA protein expression in the sh-INHBA-treated tumor tissues and sh-Ctrl tumor tissues. (d) Representative IHC images of Ki-67 protein expression in the sh-INHBA-treated tumor tissues and sh-Ctrl tumor tissues. (e, f) Masson’s trichrome staining and picrosirius red staining in tumors from mice of the sh-Ctrl or sh-INHBA groups. (g) Representative IHC images of FAP, α-SMA, and FSP1 protein expression in tumors from mice of the sh-Ctrl or sh-INHBA groups. Data are expressed as , ; ; .

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