Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis
Table 1
Characteristics of studies included in meta-analysis.
Study
Author
Country
Multicenter
No. of cases
Recruitment period
Exclude BC patients
Definition of LVI
No. of positive LVI (%)
Age (year)
Gender (male/female)
Definition of recurrence
2018
Ikeda et al.
Japan
Yes
441
1990-2015
No
Yes
156 (37)
69.0 (62-75)
319/122
Excluding bladder recurrence
2018
Kohada et al.
Japan
No
148
1999-2016
No
No
55 (37)
71.0 (64-78)
112/36
Excluding bladder recurrence
2018
Abe et al.
Japan
Yes
214
2000-2015
Yes
No
96 (45)
70.5 (35-93)
151/63
Excluding bladder recurrence
2018
Kim et al.
Korea
Yes
1521
2000-2012
Yes
No
332 (22)
65.0 (57-72)
1127/394
Excluding bladder recurrence
2018
Tan et al.
China
No
710
2013-2016
No
No
99 (15)
65.8
380/288
Excluding bladder recurrence
2018
Kim et al.
Korea
Yes
1276
2000-2012
Yes
No
258 (20)
65.7
941/335
Excluding bladder recurrence
2017
Huang et al.
China
No
481
2003-2013
Yes
No
76 (16)
65.8 (30-89)
311/170
NA
2017
Nakagawa et al.
Japan
Yes
109
1996-2013
Yes
No
78 (72)
71.0 (64-77)
67/42
Excluding bladder recurrence
2017
Cho et al.
Korea
Yes
1049
2004-2015
Yes
No
202 (19)
68.5
759/290
Including bladder recurrence
2016
Tai et al.
China
No
503
1996-2009
Yes
No
87 (18)
68.7 (59-75)
249/234
Excluding bladder recurrence
2016
Shibing et al.
China
Yes
795
2002-2012
Yes
Yes
84 (11)
NA
462/333
Excluding bladder recurrence
2016
Song et al.
China
No
140
2005-2011
Yes
No
6 (4)
NA
86/54
Excluding bladder recurrence
2016
Kobayashi et al.
Japan
Yes
839
1990-2011
Yes
Yes
326 (39)
70.4 (63-78)
610/229
Excluding bladder recurrence
2016
Waseda et al.
Japan
Yes
1068
1995-2013
Yes
No
446 (42)
70.0 (62-76)
758/310
Excluding bladder recurrence
2016
Mbeutcha et al.
International
Yes
716
1990-2008
No
No
149 (21)
70.0 (63-76)
400/316
NA
2016
Kim et al.
Korea
No
371
1992-2012
Yes
Yes
71 (19)
64.7
287/84
NA
2016
Matsumoto et al.
Japan
No
144
1995-2010
No
No
93 (65)
71.0 (14-98)
104/40
NA
2015
Hara et al.
Japan
Yes
1172
2005-2011
No
Yes
423 (36)
71.0 (21-97)
806/366
Excluding bladder recurrence
2015
Tanaka et al.
Japan
Yes
394
1995-2011
Yes
Yes
170 (43.1)
70.0
289/105
Excluding bladder recurrence
2015
Lee et al.
China
No
250
2004-2010
Yes
Yes
60 (24)
NA
108/142
Excluding bladder recurrence
2015
Kang et al.
Korea
Yes
440
2001-2013
Yes
No
76 (17)
NA
305/135
Excluding bladder recurrence
2015
Milojevic et al.
Serbia
No
238
1999-2013
Yes
No
154 (65)
66.5
132/106
Excluding bladder recurrence
2014
Aziz et al.
Germany
No
256
1990-2012
Yes
Yes
52 (20)
68.6
169/96
Excluding bladder recurrence
2013
Liu et al.
China
Yes
421
1999-2010
Yes
Yes
101 (24)
NA
285/136
NA
2013
Hurel et al.
France
Yes
551
1995-2010
Yes
Yes
163 (30)
69.4
365/188
Excluding bladder recurrence
2013
Ouzzane et al.
France
Yes
714
1995-2010
Yes
No
157 (22)
70.0
484/228
Excluding bladder recurrence
2012
Chromecki et al.
International
Yes
2492
1987-2007
Yes
Yes
247 (10)
69.2
1681/811
Excluding bladder recurrence
NA: not available; BC: bladder cancer; LVI: lymphovascular invasion.