Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis
Table 3
Subgroup analyses by region and meta-regression analyses for progression-free survival, cancer-specific survival, and overall survival.
Region
No. of studies
Weight (%)
OR (95% CI)
for heterogeneity
for interaction
PFS
18
100.00
1.73 (1.41-2.11)
77.8%
<0.001
0.055
Japan
8
41.91
2.32 (1.90-2.83)
26.3%
0.219
Korea
2
15.47
1.72 (1.47-2.01)
0.0%
0.798
China
4
18.30
1.15 (0.72-1.84)
59.3%
0.061
Othersa
4
24.32
1.47 (0.89-2.43)
83.6%
<0.001
CSS
19
100.00
1.87 (1.54-2.27)
70.3%
<0.001
0.011
Japan
7
28.60
2.57 (2.06-3.20)
0.0%
0.743
Korea
3
19.89
2.40 (1.74-3.29)
53.3%
0.117
China
5
25.94
1.25 (0.92-1.69)
51.2%
0.085
Others a
4
25.57
1.54 (1.20-1.97)
39.9%
0.172
OS
11
100.00
1.56 (1.29-1.87)
59.2%
<0.001
0.636
Japan
3
16.68
1.44 (1.01-2.07)
0.0%
0.661
Korea
3
32.24
1.95 (1.64-2.31)
0.0%
0.635
China
2
22.37
1.15 (0.71-1.89)
77.9%
0.033
Othersa
3
28.72
1.53 (1.23-1.92)
0.0%
0.463
values for meta-regression. aTwo studies from France, two from multiple countries, one from German, and one from Serbia. PFS: progression-free survival; CSS: cancer-specific survival; OS: overall survival.
