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Disease Markers
Volume 2019, Article ID 7510315, 5 pages
Research Article

Short Communication: Interaction of Nerve Growth Factor (NGF) and Vascular Endothelial Growth Factor (VEGF) in Healthy Individuals

1Department of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research, Medical School Hanover, Germany
2Celerion Switzerland AG, Switzerland
3Paracelsus Medical University Nuremberg, Germany
4Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany

Correspondence should be addressed to Adrian Groh; ed.revonnah-hm@nairda.horg

Received 11 July 2019; Revised 30 September 2019; Accepted 15 October 2019; Published 11 November 2019

Academic Editor: Anja Hviid Simonsen

Copyright © 2019 Adrian Groh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


NGF and VEGF are known to be involved in different psychiatric diseases. In order to verify hints from basic research that both neurotrophines interact with each other, serum levels of NGF and VEGF were measured in a cohort of 33 healthy individuals and correlated. NGF level was 126.30 pg/mL (±155.43), and VEGF level was 57.28 pg/mL (±44.48). Both factors were significantly correlated, confirming their interaction and legitimising the usage of their respective ratio (0.8 (±0.42)) as a less varying additional marker in prospective studies.