Disease Markers

Research Article

Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients

Table 3

Differentiating metabolites between STEMI and healthy individuals (controls).


No.	Metabolites	Classes	VIP^a	FC^b	value^c	value^d	STEMI	Controls

1	PC ae C36:4	Phosphatidylcholines	1,49	-3.69	0.0003	0.0049	Up	Down
2	PC ae C36:3	Phosphatidylcholines	1,48	1.98	0.0021	0.0140	Down	Up
3	PC ae C34:2	Phosphatidylcholines	1,47	1.05	0.8082	0.8841	Down	Up
4	PC ae C38:5	Phosphatidylcholines	1,44	-3.65	0.0014	0.0119	Up	Down
5	PC ae C38:6	Phosphatidylcholines	1,42	2.27	< 0.0001	0.0000	Down	Up
6	PC ae C34:3	Phosphatidylcholines	1,39	1.92	0.0020	0.0140	Down	Up
7	PC aa C34:4	Phosphatidylcholines	1,39	-2.4	0.0076	0.0285	Up	Down
8	PC ae C40:3	Phosphatidylcholines	1,38	-2.29	0.0442	0.0913	Up	Down
9	PC aa C40:2	Phosphatidylcholines	1,37	1.22	0.5324	0.6310	Down	Up
10	PC ae C40:6	Phosphatidylcholines	1,35	1.64	0.0022	0.0142	Down	Up
11	lysoPC a C14:0	Lysophosphatidylcholines	1,35	1.68	0.0004	0.0049	Down	Up
12	PC aa C36:1	Phosphatidylcholines	1,33	1.7	< 0.0001	0.0017	Down	Up
13	PC aa C36:3	Phosphatidylcholines	1,33	-3.29	0.0302	0.0729	Up	Down
14	PC ae C36:5	Phosphatidylcholines	1,32	-1.21	0.7157	0.8035	Up	Down
15	PC ae C32:1	Phosphatidylcholines	1,32	1.14	0.0076	0.0285	Down	Up
16	PC aa C36:0	Phosphatidylcholines	1,32	-1.44	0.0136	0.0426	Up	Down
17	PC aa C40:3	Phosphatidylcholines	1,30	3.0	0.0264	0.0663	Down	Up
18	PC ae C38:4	Phosphatidylcholines	1,29	-3.69	0.0003	0.0049	Up	Down
19	PC aa C38:3	Phosphatidylcholines	1,29	1.54	0.0003	0.0049	Down	Up
20	PC aa C42:4	Phosphatidylcholines	1,28	-1.6	0.0045	0.0190	Up	Down
21	SM C26:0	Sphingomyelins	1,27	2.42	0.0002	0.0036	Down	Up
22	lysoPC a C18:2	Lysophosphatidylcholines	1,25	1.58	0.0045	0.0190	Down	Up
23	PC aa C30:0	Phosphatidylcholines	1,23	1.82	0.0004	0.0049	Down	Up
24	PC ae C42:1	Phosphatidylcholines	1,22	-1.35	0.1401	0.2330	Up	Down
25	PC ae C38:3	Phosphatidylcholines	1,22	2.23	0.0860	0.1594	Down	Up
26	PC ae C36:2	Phosphatidylcholines	1,21	-4.02	0.0315	0.0733	Up	Down
27	PC ae C34:1	Phosphatidylcholines	1,20	1.05	0.5324	0.6310	Down	Up
28	Nitro-Tyr	Biogenic amines	1,20	-2.18	0.0008	0.0075	Up	Down
29	PC aa C38:5	Phosphatidylcholines	1,20	1.87	<0.0001	0.0017	Down	Up
30	SM (OH) C24:1	Sphingomyelins	1,19	-1.14	0.1760	0.2715	Down	Down
31	lysoPC a C20:3	Lysophosphatidylcholines	1,19	1.04	0.3764	0.4824	Down	Up
32	PC ae C38:1	Phosphatidylcholines	1,17	-2.11	0.0183	0.0533	Up	Down
33	PC ae C44:3	Phosphatidylcholines	1,16	-1.32	0.3488	0.4603	Down	Down
34	Ac-Orn	Biogenic amines	1,16	1.82	0.0039	0.0190	Down	Up
35	PC aa C40:5	Phosphatidylcholines	1,15	-2.44	0.0201	0.0548	Up	Down
36	PC ae C32:2	Phosphatidylcholines	1,15	1.55	0.0005	0.0052	Down	Up
37	PC ae C30:1	Phosphatidylcholines	1,15	1.98	0.0159	0.0474	Down	Up
38	PC ae C40:4	Phosphatidylcholines	1,14	-1.68	0.0044	0.0190	Down	Down
39	PC aa C40:1	Phosphatidylcholines	1,13	-1.44	0.0376	0.0829	Up	Down
40	SM (OH) C14:1	Sphingomyelins	1,13	1.07	0.2746	0.3779	Down	Up
41	PC ae C34:0	Phosphatidylcholines	1,13	-1.42	0.9171	0.9403	Up	Down
42	SM C24:0	Sphingomyelins	1,13	1.41	0.0001	0.0035	Down	Up
43	PC aa C38:4	Phosphatidylcholines	1,13	-2.04	0.1600	0.2561	Up	Down
44	lysoPC a C16:1	Phosphatidylcholines	1,12	1.59	0.0080	0.0293	Down	Up
45	PC aa C40:6	Phosphatidylcholines	1,11	-1.02	0.0329	0.0738	Up	Down
46	SM (OH) C22:1	Sphingomyelins	1,11	1.55	0.0119	0.0391	Down	Up
47	PC aa C38:0	Phosphatidylcholines	1,11	1.29	0.0113	0.0388	Down	Up
48	SM (OH) C22:2	Sphingomyelins	1,11	1.62	0.0018	0.0136	Down	Up
49	PC aa C42:2	Phosphatidylcholines	1,10	-1.44	0.0201	0.0548	Up	Down
50	PC ae C44:5	Phosphatidylcholines	1,10	-1.58	0.2382	0.3397	Up	Down
51	PC ae C44:6	Phosphatidylcholines	1,07	-1.72	0.3580	0.4675	Up	Down
52	lysoPC a C18:1	Lysophosphatidylcholines	1,07	1.27	0.0329	0.0738	Down	Up
53	PC aa C24:0	Phosphatidylcholines	1,07	-1.77	0.0090	0.0321	Up	Down
54	PC aa C38:6	Phosphatidylcholines	1,06	1.69	0.0009	0.0084	Down	Up
55	PC aa C28:1	Phosphatidylcholines	1,03	1.48	0.0263	0.0663	Down	Up
56	PC ae C30:0	Phosphatidylcholines	1,03	1.58	0.1761	0.2715	Down	Up
57	PC ae C38:2	Phosphatidylcholines	1,02	-1.81	0.0033	0.0184	Up	Down
58	lysoPC a C18:0	Lysophosphatidylcholines	1,01	1.21	0.0315	0.0733	Down	Up
59	PC aa C40:4	Phosphatidylcholines	1,01	1.41	0.0040	0.0190	Down	Up
60	PC aa C32:0	Phosphatidylcholines	1,01	-1.5	0.9862	0.9862	Up	Down

^aVariable importance in the projection (VIP) was obtained from OPLS-DA with a threshold of 1.0. ^bThe fold change (FC) was calculated by the average value of the STEMI group to that of the control group. ^c value was calculated by the Wilcoxon-Mann-Whitney test. values < 0.05 are in bold. ^d value was the adjusted value with the false discovery rate (FDR).