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Figure 3: Association between adipose tissue IL-33 and HbA1c (and fasting glucose in T2D) in individuals with varying degrees of glycemia. (a) IL-33 was inversely correlated with HbA1c in individuals with normoglycemia () and T2D () but not in those with prediabetes (). (b) Higher levels of IL-33 were associated with lower HbA1c in individuals with normoglycemia (although statistically nonsignificant) and T2D (statistically significant) but not in those with prediabetes. (c) The ratio of IL-33 to ST2 was inversely correlated with HbA1c in individuals with normoglycemia () but not in those with prediabetes () or T2D (). (d) IL-33 was inversely correlated with fasting glucose in individuals with T2D who had a better glycemic control (). IL-33: interleukin-33; ST2: suppressor of tumorigenicity 2; HbA1c: glycated hemoglobin; NL: normoglycemia; T2D: type 2 diabetes; Meds: glucose-lowering medications.