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Figure 5: Association between adipose tissue IL-33 and TLR3 and TLR9 in individuals with varying degrees of glycemia. (a) IL-33 was directly correlated with TLR3 in individuals with T2D () but not in those with normoglycemia () or prediabetes (). (b) Higher levels of IL-33 were associated with higher TLR3 in individuals with T2D (although statistically nonsignificant) but not in those with normoglycemia or prediabetes. (c) IL-33 was directly correlated with TLR9 in individuals with prediabetes () but not in those with normoglycemia () or T2D (). (d) Higher levels of IL-33 were associated with significantly higher TLR9 in individuals with prediabetes but not in those with normoglycemia or T2D. IL-33: interleukin-33; TLR3: toll-like receptor 3; TLR9: toll-like receptor 9; PreD: prediabetes; T2D: type 2 diabetes; Meds: glucose-lowering medications.